Excess mortality and morbidity among small-for-gestational-age premature infants: a population-based study

Rivka H Regev; Ayala Lusky; Tzipora Dolfin; Ita Litmanovitz; Shmuel Arnon; Brian Reichman; Israel Neonatal Network

doi:10.1067/S0022-3476(03)00181-1

Pregnancy · Neonatal Outcomes

Excess mortality and morbidity among small-for-gestational-age premature infants: a population-based study

Regev RH, Lusky A, Dolfin T, Litmanovitz I, Arnon S, Reichman B, Israel Neonatal Network

Published August 2003 The Journal of Pediatrics, 143(2), 186-191

DOI 10.1067/S0022-3476(03)00181-1 PMID 12970630

Abstract

Objective

We examined the effect of intrauterine growth restriction on mortality and morbidity in the Israel cohort of very low birth weight premature infants.

Methods

The study population included 2764 singleton very low birth weight infants without congenital malformations born from 24 to 31 weeks of gestation during 1995 to 1999. Four hundred six (15%) were born small for gestational age (SGA). The effect of SGA on death, bronchopulmonary dysplasia, and retinopathy of prematurity was assessed using multiple logistic regression analysis.

Results

After adjustment for perinatal risk factors, SGA infants had a 4.52-fold risk for death (95% CI, 3.24-6.33), a 3.42-fold risk for bronchopulmonary dysplasia (95% CI, 2.29-5.13), and a 2.06-fold risk for grade 3 to 4 retinopathy of prematurity (95% CI, 1.15-3.66).

Conclusions

SGA premature infants had an increased risk for death, and major morbidity among survivors was increased.

Topics

Pregnancy Neonatal Outcomes Birth Weight

Pregnancy › Neonatal Outcomes › Birth Weight

Rivka H Regev, Ayala Lusky, Tzipora Dolfin, Ita Litmanovitz, Shmuel Arnon, Brian Reichman

R Regev, A Lusky, T Dolfin, I Litmanovitz, S Arnon, B Reichman

PMID 12970630 12970630 DOI 10.1067/S0022-3476(03)00181-1 10.1067/S0022-3476(03)00181-1 Regev et al. 2003, Regev 2003

Keywords

Bronchopulmonary Dysplasia/epidemiology/mortality, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases/epidemiology/mortality, Infant, Small for Gestational Age, Logistic Models, Retinopathy of Prematurity/epidemiology/mortality

Excess mortality and morbidity among small-for-gestational-age premature infants: a population-based study

Abstract

Topics

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