The role of placental insufficiency in spontaneous preterm birth: A literature review

Megan Preston; Megan Hall; Andrew Shennan; Lisa Story

doi:10.1016/j.ejogrb.2024.02.020

Pregnancy · Preterm Birth

The role of placental insufficiency in spontaneous preterm birth: A literature review

Preston M, Hall M, Shennan A, Story L

Published April 2024 European journal of obstetrics, gynecology, and reproductive biology, 295, 136-142

DOI 10.1016/j.ejogrb.2024.02.020 PMID 38359634

Abstract

Preterm Birth (delivery before 37 weeks of gestation) is the leading cause of childhood mortality and is also associated with significant morbidity both in the neonatal period and beyond. The aetiology of spontaneous preterm birth is unclear and likely multifactorial incorporating factors such as infection/inflammation and cervical injury. Placental insufficiency is emerging as an additional contributor to spontaneous preterm delivery; however, the mechanisms by which this occurs are not fully understood. Serum biomarkers and imaging techniques have been investigated as potential predictors of placental insufficiency, however none have yet been found to have a sufficient predictive value. This review examines the evidence for the role of the placenta in preterm birth, preterm prelabour rupture of the membranes and abruption as well as highlighting areas where further research is required.

Topics

Pregnancy › Preterm Birth › Prediction · Birth and Delivery › Birth Outcomes › Maternal Morbidity

Megan Preston, Megan Hall, Andrew Shennan, Lisa Story

M Preston, M Hall, Andy Shennan, Drew Shennan, A Shennan, L Story

PMID 38359634 38359634 DOI 10.1016/j.ejogrb.2024.02.020 10.1016/j.ejogrb.2024.02.020 Preston et al. 2024, Preston 2024

Keywords

Placental abruption, Placental insufficiency, Preterm prelabor rupture of membranes, Spontaneous preterm labor

The role of placental insufficiency in spontaneous preterm birth: A literature review

Abstract

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