The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network

Goldenberg RL; Iams JD; Mercer BM; Meis PJ; Moawad AH; Copper RL; Das A; Thom E; Johnson F; McNellis D; Miodovnik M; Van Dorsten JP; Caritis SN; Thurnau GR; Bottoms SF

doi:10.2105/ajph.88.2.233

Pregnancy · Preterm Birth

The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network

Goldenberg RL, Iams JD, Mercer BM, Meis PJ, Moawad AH, Copper RL, Das A, Thom E, Johnson F, McNellis D, Miodovnik M, Van Dorsten JP, Caritis SN, Thurnau GR, Bottoms SF

Published February 1998 American Journal of Public Health, 88(2), 233-238

DOI 10.2105/ajph.88.2.233 PMID 9491013

Abstract

Objectives

This study was undertaken to determine the relationship between fetal fibronectin, short cervix, bacterial vaginosis, other traditional risk factors, and spontaneous preterm birth.

Methods

From 1992 through 1994, 2929 women were screened at the gestational age 22 to 24 weeks.

Results

The odds ratios for spontaneous preterm birth were highest for fetal fibronectin, followed by a short cervix and history of preterm birth. These factors, as well as bacterial vaginosis, were more strongly associated with early than with late spontaneous preterm birth. Bacterial vaginosis was more common--and a stronger predictor of spontaneous preterm birth--in Black women, while body mass index less than 19.8 was a stronger predictor in non-Black women. This analysis suggests a pathway leading from Black race through bacterial vaginosis and fetal fibronectin to spontaneous preterm birth. Prior preterm birth is associated with spontaneous preterm birth through a short cervix.

Conclusions

Fetal fibronectin and a short cervix are stronger predictors of spontaneous preterm birth than traditional risk factors. Bacterial vaginosis was found more often in Black than in non-Black women and accounted for 40% of the attributable risk for spontaneous preterm birth at less than 32 weeks.

Topics

Pregnancy › Preterm Birth › Prediction · Birth and Delivery › Birth Outcomes › Maternal Morbidity · Diagnostics › Microbiome and Infection Testing › Culture and Infection Testing

Jay D Iams, Atef H Moawad, Steve N Caritis, Paul J Meis, Menachem Miodovnik, J P Van Dorsten

J Iams, A Moawad, Stephen Caritis, Steven Caritis, S Caritis, P Meis, M Miodovnik

PMID 9491013 9491013 DOI 10.2105/ajph.88.2.233 10.2105/ajph.88.2.233 Goldenberg et al. 1998, Goldenberg 1998

Keywords

Cervix Uteri/anatomy & Histology, Female, Fetal Blood, Fibronectins/blood, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Logistic Models, Obstetric Labor, Premature/epidemiology, Pregnancy, Risk Factors, United States/epidemiology, Vaginosis, Bacterial, Fibronectins

The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network

Abstract

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