Uterine and Pelvic Conditions · Acquired Uterine Conditions

Treatment for Uterine Isthmocele, A Pouchlike Defect at the Site of a Cesarean Section Scar

Setubal A, Alves J, Osório F, Guerra A, Fernandes R, Albornoz J, Sidiroupoulou Z

Published January 2018 Journal of Minimally Invasive Gynecology, 25(1), 38-46
DOI 10.1016/j.jmig.2017.09.022 PMID 29024799

RRM Academy Synopsis

No Surgical Method Proven Superior for Isthmocele Repair

No surgical approach for isthmocele has been proven best. Isthmocele is a gap in the scar left by a cesarean birth. A 2018 review compared four repair methods: vaginal repair, laparotomy, hysteroscopy, and laparoscopy. Pregnancy rates after surgery ranged from 22% to 71% across separate studies.

Key Findings

  • Isthmocele, also called a niche or cesarean scar defect, is reported in 19% to 84% of women who have had a cesarean section.
  • The review searched the literature from 1980 to 2017 and found 215 studies. It excluded 175 for not addressing isthmocele management and 10 more for being reviews or prior case reports.
  • Across the case series reviewed, reported pregnancy rates after surgery were 22% after vaginal repair, 71% after laparotomy, and 44% after laparoscopy in a 38-patient series.
  • Symptom relief was reported in 85% to 93% of patients after vaginal repair. One cited study reported a 97% improvement in pain after hysteroscopic removal of the defect.
  • Women with an isthmocele had abnormal bleeding at rates of 28.9% to 30% in two cited studies, compared with 6.9% of women without an isthmocele.

Interpretation

This narrative review pooled case series on isthmocele repair from 1980 to 2017. Women in these studies had a symptomatic isthmocele, mostly found by ultrasound or MRI. The authors note that no single repair method has yet been proven better than the others. The findings support larger, prospective studies that compare the methods head to head.

RRM Context

Isthmocele shows how a scar from a past surgery can cause bleeding, pain, or infertility years later. Restorative reproductive medicine looks for anatomic causes like this one as part of a root-cause workup. A root-cause workup can turn an undiagnosed case into one with a named, treatable condition. NaProTechnology surgeons study pelvic anatomy by ultrasound. They can find a scar defect like this one during that workup.

Abstract

An isthmocele appears as a fluid pouchlike defect in the anterior uterine wall at the site of a prior cesarean section and ranges in prevalence from 19% to 84%, a direct relation to the increase in cesarean sections performed worldwide. Many definitions have been suggested for the dehiscence resulting from cesarean sections, and we propose standardization with a single term for all cases-isthmocele. Patients are not always symptomatic, but symptoms typically include intermittent abnormal bleeding, pain, and infertility. Pregnancy complications that result from an isthmocele include ectopic pregnancy, low implantation, and uterine rupture. Magnetic resonance imaging and transvaginal ultrasound are the gold standard imaging techniques for diagnosis. Surgical treatment of an isthmocele is still a controversial issue but should be offered to symptomatic women or the asymptomatic patient who desires future pregnancy. When surgery is the treatment choice, laparoscopy guided by hysteroscopy, hysteroscopy alone, or vaginal repair are the best options depending on the isthmocele's characteristics and surgeon expertise.

Topics

Related research

Uterine and Pelvic Conditions › Acquired Uterine Conditions › Cesarean Scar Defect · Reproductive Surgery › Uterine Surgery › Cesarean Scar Repair · Diagnostics › Tubal and Uterine Imaging › Hysteroscopy
Antonio Setubal, João Alves, Filipa Osório, Adalgisa Guerra, Rodrigo Fernandes, Jaime Albornoz, Zacharoula Sidiroupoulou
A Setubal, J Alves, F Osório, A Guerra, R Fernandes, J Albornoz, Z Sidiroupoulou
PMID 29024799 29024799 DOI 10.1016/j.jmig.2017.09.022 10.1016/j.jmig.2017.09.022 Setubal et al. 2018, Setubal 2018