Oxidative Stress / Reactive Oxygen Species (ROS)

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 7, 2026

An imbalance between pro-oxidant species (ROS, reactive nitrogen species) and antioxidant defenses. At physiological levels, ROS play important roles in folliculogenesis, oocyte maturation, capacitation, and embryo development. Excess ROS, however, damages sperm DNA, impairs sperm motility, disrupts oocyte quality, damages embryos, and is linked to endometriosis, PCOS, unexplained infertility, recurrent miscarriage, and preeclampsia. RRM addresses oxidative stress through targeted antioxidant supplementation (vitamin C, E, CoQ10, zinc, selenium, L-carnitine, N-acetylcysteine), lifestyle modification (smoking cessation, weight management), and treatment of underlying conditions.⁵⁷⁵⁸³⁵

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.