Preconception TSH and pregnancy outcomes: a population-based cohort study in 184 611 women

Chen S, Zhou X, Zhu H, Yang H, Gong F, Wang L, Zhang M, Jiang Y, Yan C, Li J, Wang Q, Zhang S, Pan H

doi:10.1111/cen.13329

Clinical Endocrinology, 2017

Preconception TSH and pregnancy outcomes: a population-based cohort study in 184 611 women

Shee-Uan Chen , Xiangjun Zhou , Hang Zhu

Author affiliations (10)

National Yang Ming Chiao Tung University
Wenzhou University ROR
Chongqing Medical University ROR
McGill University ROR
Second Affiliated Hospital of Zhejiang University ROR
Amgen (United States) ROR
Wuhan Union Hospital ROR
Guangxi University ROR
Anhui Medical University ROR
Shanghai Ninth People's Hospital ROR

DOI10.1111/cen.13329 PMID28295470

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Abstract

This population-based cohort study examined preconception TSH levels and their association with pregnancy outcomes in 184,611 Chinese women planning to conceive. Women were classified into reference (0.48-2.49 mIU/L), upper limit (2.5-4.28 mIU/L), and high TSH (4.29-10 mIU/L) groups. The high normal TSH group showed higher rates of spontaneous abortion, preterm birth, and operative vaginal delivery compared to reference. The high TSH group had higher rates of spontaneous abortion, stillbirth, and preterm births.

PMID 28295470 28295470 DOI 10.1111/cen.13329 10.1111/cen.13329