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Results of in vivo and in vitro studies for assessing prenatal toxicity

M Kastner, Joachim Kröger, Hans‐Joachim Merker, Thomas Schulz, Ralf Stahlmann, G Blankenburg, I Chahoud, G Franz, R Herken, S Klug, R Krowke, C Lewandowski, D Neubert

Open Access

Environmental Health Perspectives, 70, 89-103

DOI 10.1289/ehp.867089 PMID 3104025

Abstract

Examples of a combined approach using in vivo as well as in vitro methods for the assessment of prenatal toxicity are presented. The topics discussed include the analysis of the possible embryotoxic potential of valproic acid (VPA), female sex hormones, bis(tri-n-butyltin) oxide (TBTO), and acyclovir and the problem of supplementing in vitro systems with drug-metabolizing activity.

Topics

PregnancyResearch Methodology
prenatal toxicity assessment, embryotoxic potential valproic acid, in vitro embryotoxicity testing, teratogenicity sex hormones, prenatal toxicology methods, developmental toxicity screening, reproductive toxicology in vivo in vitro, embryo culture toxicity assay, acyclovir prenatal safety, environmental toxicant reproductive effects
PMID 3104025 3104025 DOI 10.1289/ehp.867089 10.1289/ehp.867089

Cite this article

Neubert, D., Blankenburg, G., Chahoud, I., Franz, G., Herken, R., Kastner, M., Klug, S., Kröger, J., Krowke, R., & Lewandowski, C. (1986). Results of in vivo and in vitro studies for assessing prenatal toxicity. *Environmental health perspectives*, *70*, 89-103. https://doi.org/10.1289/ehp.867089

Keywords

Abnormalities, Drug-Induced/pathology, Acyclovir/toxicity, Animals, Disinfectants/toxicity, Embryo, Mammalian/drug Effects, Estrogens/toxicity, Mice, Mice, Inbred C57BL, Organ Culture Techniques/methods, Progesterone/toxicity, Rats, Teratogens, Trialkyltin Compounds/toxicity, Valproic Acid/toxicity, Disinfectants, Estrogens, Teratogens, Trialkyltin Compounds, Bis(tri-n-butyltin)oxide, Progesterone, Valproic Acid, Acyclovir

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