Reproductive Endocrinology Neuroendocrinology

Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH)

Crowley WF Jr, McArthur JW

Published July 1980 The Journal of Clinical Endocrinology and Metabolism, 51(1), 173-175
DOI 10.1210/jcem-51-1-173 PMID 6247361

Abstract

The administration of small doses of LHRH at 2-hourly intervals over a 27 day period to a 24-year old patient with Kallman's syndrome resulted in ovulation as indicated by: (1) a biphasic temperature response, (2) anatomical changes in the ovaries demonstrated by ultrasound, and (3) the pattern of circulating gonadotropin and gonadal steroid concentrations.

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Reproductive Endocrinology › Neuroendocrinology › Hypothalamic Pituitary Axis · Therapeutics › Hormonal Agents › Gonadotropins · Menstrual Cycle › Cycle Disorders › Ovulatory Disturbances
PMID 6247361 6247361 DOI 10.1210/jcem-51-1-173 10.1210/jcem-51-1-173 Crowley Jr et al. 1980, Crowley Jr 1980