Various clinical presentations of impaired endometrial receptivity: a series of 3 cases

Endometrial receptivity disorders are common for subfertility, but patients selection for this procedure is not easy. The publications on the item of endometrial receptivity usually focus on implantation failures in IVF setting, or multiple pregnancy losses in both in vitro and in vivo pregnancies without mentioning clinical signs and symptoms (1,2) . There are few data about correlation of clinical presentations and impaired endometrial receptivity in women with reproductive disorders looking for restorative reproductive treatment. We present the case series of 3 subfertile women in whom endometrial biopsy with immunohistichemical evaluation was performed. In these patients, similar non-CD138-associated immunohistochemical findings coexisted with various clinical presentations.. In all these patients, similar immunologic treatment chosen on the basis of endometrial evaluation led to live birth. Thus, endometrial receptivity evaluation can be a useful tool in subfertile women looking for in vivo conception. Understanding clinical presentations in which endometrial biopsy can be the most useful can improve diagnostic and shorten time to effective treatment and successful pregnancy.