Oral Micronized Progesterone (OMP)
Oral micronized progesterone (OMP) is progesterone ground into very fine grains, so the body can take it up when it is swallowed. Progesterone is the hormone the ovary makes after ovulation. The form is also written as micronized progesterone. Progestins are man-made versions of the molecule, and they act in other ways.
Grain size and carrier matter. A 1989 study gave five oral forms to seven people. The form ground in oil reached the highest blood level, and reached it fastest, in about two hours1.
The oral form has a place in cycle-timed support. A 1995 series treated seven women with luteal phase deficiency. All seven then had in-phase biopsies. Most preferred the capsule by mouth to the vaginal route, even though it made them drowsy2.
Cited in this entry
- Hargrove JT, Maxson WS, Wentz AC. Absorption of oral progesterone is influenced by vehicle and particle size. American Journal of Obstetrics and Gynecology. 1989. https://pubmed.ncbi.nlm.nih.gov/2801843/
- Frishman GN, Klock SC, Luciano AA, Nulsen JC. Efficacy of oral micronized progesterone in the treatment of luteal phase defects. The Journal of Reproductive Medicine. 1995. https://pubmed.ncbi.nlm.nih.gov/7473442/
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.