Luteal phase defects in infertility patients with endometriosis

Donald E. Pittaway; Wayne Maxson; James Daniell; Carl Herbert; Anne Colston Wentz

doi:10.1016/s0015-0282(16)47072-x

Reproductive Endocrinology · Luteal Phase

Luteal phase defects in infertility patients with endometriosis

Pittaway DE, Maxson W, Daniell J, Herbert C, Wentz AC

Published May 1983 Fertility and Sterility, 39(5), 712-713

DOI 10.1016/s0015-0282(16)47072-x PMID 6840312

RRM Academy Synopsis

Infertile women with endometriosis had no more luteal phase defects

Luteal phase defect was no more common in infertile women with endometriosis than in those without it. A 1983 survey of 143 infertile women with regular menses found the defect in about 9 out of 100 with endometriosis and about 5 out of 100 without. The difference was not significant (P > 0.5).

Key Findings

Among 143 infertile women with regular menses and unstimulated ovulatory cycles, 10 (7.0%) had a luteal phase defect on a late luteal phase endometrial biopsy.
Luteal phase defect occurred in 6 of 68 women with endometriosis (8.8%) and 4 of 75 women without endometriosis (5.3%). The difference was not significant (P > 0.5).
Mild and moderate endometriosis had the defect in 5 of 57 women (8.8%), and severe and extensive endometriosis in 1 of 11 (9.1%); neither differed significantly from 5.3% without endometriosis.

Interpretation

The study is a brief survey of women referred to one university infertility center. The authors dated a timed endometrial biopsy taken late in the luteal phase to diagnose luteal phase defect. Only 10 women had the defect, so each comparison rested on a few cases. Women needing ovulation induction were excluded, and all had regular menses. The authors note that subtler hormonal or endometrial changes, which a late luteal biopsy does not reflect, remain to be explored.

RRM Context

Restorative reproductive medicine looks for the cause of infertility in each couple. Here, laparoscopy or laparotomy diagnosed the endometriosis. Of 68 infertile women who had it, 6 had a luteal phase defect.

Our editorial summary of this paper, not the article's abstract.

Abstract

The cause of infertility has remained obscure in women with endometriosis in whom the tuboovarian relationship is unaltered. Abnormal corpus luteum function has been one mechanism implicated in the pathophysiology of endometriosis in infertilityl-3 and may also be a possible explanation for the high frequency of spontaneous abortions among women with untreated endometriosis.4 However, we have observed only an occasional occurrence of luteal phase deficiency in women with an ultimate diagnosis of endometriosis. In order to verify this observation, we examined the incidence of luteal phase defects (LPDs) in. our infertility population.

Topics

Reproductive Endocrinology › Luteal Phase › Luteal Phase Deficiency · Endometriosis › Fertility and Outcomes › Ovarian Reserve · Infertility › Luteal Phase Defect › Diagnosis

Donald E. Pittaway, Wayne Maxson, James Daniell, Carl Herbert, Anne Colston Wentz

Don Pittaway, D Pittaway, W Maxson, Jim Daniell, Jimmy Daniell, J Daniell, C Herbert, A Wentz

PMID 6840312 6840312 DOI 10.1016/s0015-0282(16)47072-x 10.1016/s0015-0282(16)47072-x Pittaway et al. 1983, Pittaway 1983

Keywords

Endometriosis/complications/physiopathology, Female, Humans, Infertility, Female/complications/physiopathology, Luteal Phase, Menstruation

Luteal phase defects in infertility patients with endometriosis

Infertile women with endometriosis had no more luteal phase defects

Key Findings

Interpretation

RRM Context

Abstract

Topics

By this author

Related research

Keywords