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Oral contraceptive use and depression among adolescents

McKetta S et al., 2019 Annals of Epidemiology

Purpose: Depression is a prevalent health problem affecting U.S. women. Oral contraceptive pills (OCPs) are commonly used for pregnancy prevention, and evidence is mixed regarding any increased risk f...

Contraception/Comparison > Side Effects > Depression and Mood DisordersResearch Methodology > Epidemiology > National Comorbidity Survey AnalysisGeneral OB/GYN > Adolescent Health > Oral Contraceptive Safety

Isthmocele: From Risk Factors to Management

Iannone P et al., 2019 Open Access Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia

Objective: The aim of the present study was to perform a comprehensive review of the literature to provide a complete and clear picture of isthmocele-a hypoechoic area within the myometrium at the sit...

Surgery > Uterine Surgery > Cesarean Scar Defect RepairGeneral OB/GYN > Uterine Pathology > Isthmocele Diagnosis and ManagementPregnancy > Cesarean Section > Long-Term Scar Complications

Adolescent use of combined hormonal contraception and peak bone mineral density accrual: A meta-analysis of international prospective controlled studies

Goshtasebi A et al., 2019 Open Access Clinical Endocrinology

Objective: Many women use combined hormonal contraceptives (CHC) during adolescence during which they are accruing peak areal bone mineral density (BMD) that relates to lifetime fracture risk. To buil...

Bone Health > Contraception Impact > Adolescent Peak BMD AccrualContraception/Comparison > Combined Hormonal > Bone Health EffectsResearch Methodology > Meta-Analysis > Prospective Controlled Studies

Progesterone Is Important for Transgender Women's Therapy-Applying Evidence for the Benefits of Progesterone in Ciswomen

Prior JC, 2019 The Journal of Clinical Endocrinology and Metabolism

Background: Although the 2017 Endocrine Society Guidelines for gender dysphoria stipulated that cross-sex hormone therapy (CHT) achieve gonadal steroid levels equivalent to those of a cisperson of the...

Reproductive Endocrinology > Progesterone > Transgender Women TherapyReproductive Endocrinology > Hormone Therapy > Cross-Sex HormonesBone Health > Hormonal Factors > Progesterone and Bone Formation

Mortality risk reduction differs according to bisphosphonate class: a 15-year observational study

D Bliuc et al., 2019 Osteoporos Int

In this prospective cohort of 6120 participants aged 50+, nitrogen-bisphosphonates but not non-nitrogen bisphosphonates were associated with a significant 34% mortality risk reduction compared to non-...

Bone Health > Pharmacological Treatment > BisphosphonatesPerimenopause/Menopause > Osteoporosis > Treatment OutcomesResearch Methodology > Observational Studies > Prospective Cohort

Ultrasound in reproductive medicine: is it safe?

Abramowicz JS, 2019 Ultrasound Imaging in Reproductive Medicine

Ultrasound is a form of energy with effects in tissues it traverses (bioeffects). The major bioeffects are a rise in temperature (thermal effects) and some effects secondary to the alternating positiv...

Infertility > Assisted Reproduction > Ultrasound SafetyDiagnostics > Ultrasound > Bioeffects and SafetyPregnancy > Prenatal Monitoring > Ultrasound Exposure

Laparoscopic Adrenalectomy: Two Years Experience at Bangabandhu Sheikh Mujib Medical University

Joarder AI et al., 2019 Mymensingh medical journal : MMJ

Laparoscopic surgery has become an efficient tool for many complex surgical procedures. In last decades, laparoscopic adrenalectomy has become a more viable option for removal of adrenal pathology, wi...

Surgery > Laparoscopic Procedures > AdrenalectomyReproductive Endocrinology > Adrenal Disorders > Adrenal TumorsResearch Methodology > Case Series > Surgical Outcomes

Low Dose Naltrexone in Pregnancy

Boyle PC, 2019

Presentation examining the safety and potential benefits of low-dose naltrexone (LDN) use during pregnancy. Reports on a patient survey of 237 successful pregnancies comparing outcomes between LDN use...

Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

Sfakianoudis K et al., 2018 Open Access Journal of Clinical Medicine

This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platele...

Infertility > Premature Ovarian Failure > Platelet-Rich Plasma TreatmentReproductive Endocrinology > Ovarian Reserve > Experimental RejuvenationPerimenopause/Menopause > Premature Menopause > Fertility Restoration

The influence of different inositol stereoisomers supplementation in pregnancy on maternal gestational diabetes mellitus and fetal outcomes in high-risk patients: a randomized controlled trial

Celentano C et al., 2018 The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Objective: To identify the effects of different dietary inositol stereoisomers on insulin resistance and the development of gestational diabetes mellitus (GDM) in women at high risk for this disorder....

Pregnancy > Gestational Diabetes > Prevention and TreatmentPregnancy > Nutritional Supplementation > InositolResearch Methodology > Clinical Trials > Randomized Controlled Trial

An inexpensive smartphone-based device for point-of-care ovulation testing

Potluri V et al., 2018 Lab on a Chip

The ability to accurately predict ovulation at-home using low-cost point-of-care diagnostics can be of significant help for couples who prefer natural family planning. Detecting ovulation-specific hor...

Fertility Awareness > Technology > Smartphone Ovulation DetectionDiagnostics > Ovulation Testing > Salivary Ferning Point-of-CareBody Literacy > Natural Family Planning > Affordable Fertility Monitoring

Rejecting Humanae Vitae: The Social Costs of Denying the Obvious

Klaus H, 2018 The Linacre Quarterly

Since contraceptives have been used to remove fertility from the conjugal act, the social consequences predicted in the encyclical Humanae vitae, such as the rise in cohabitation, decline of marriage,...

Ethics/Philosophy > Catholic Social Teaching > Humanae Vitae ConsequencesContraception/Comparison > Societal Impact > Demographic and Family EffectsBody Literacy > Sexual Ethics > Marriage and Complementarity

Dissociation between Cervical Mucus and Urinary Hormones during the Postpartum Return of Fertility in Breastfeeding Women

Bouchard T et al., 2018 The Linacre Quarterly

Identifying the return of fertility with cervical mucus observations is challenging during the postpartum period. Use of urinary measurements of estrogen and progesterone can assist in understanding t...

Fertility Awareness > Postpartum > Cervical Mucus-Hormone DissociationPostpartum > Return of Fertility > Breastfeeding Hormonal PatternsRRM Methods > Biomarker Monitoring > Urinary Hormone Validation

Systematic Review of Hormonal Contraception and Risk of Venous Thrombosis

Keenan L et al., 2018 The Linacre Quarterly

Background: Hormonal contraception (HC) is widely used throughout the world and has been associated with venous thrombosis (VT) such as deep vein thrombosis, pulmonary emboli, and cerebral VT. Object...

Contraception/Comparison > Side Effects > Venous ThromboembolismResearch Methodology > Systematic Review > Contraception SafetyGeneral OB/GYN > Cardiovascular Risk > Hormonal Contraception

The State of the Fertility Sector 2017/2018

Human Fertilisation and Embryology Authority, 2018
Contraception/Comparison > Assisted Reproduction > Industry ReportsInfertility > Assisted Reproduction > Epidemiology and Trends

Systematic Review of Ovarian Activity and Potential for Embryo Formation and Loss during the Use of Hormonal Contraception

Harrison D et al., 2018 The Linacre Quarterly

The purpose of this review was to determine whether there is evidence that ovulation can occur in women using hormonal contraceptives and whether these drugs might inhibit implantation. We performed a...

Contraception/Comparison > Mechanism of Action > Breakthrough OvulationEthics/Philosophy > Contraception Ethics > Post-Fertilization EffectsReproductive Endocrinology > Ovarian Function > Contraceptive Suppression

Hormonal Contraception and the Informed Consent

Hilger DJ et al., 2018 The Linacre Quarterly

Since the 1960s, hormonal contraceptives have become the most commonly used method of pregnancy prevention in the United States and the world. Oral contraceptives are used by a large percentage of wom...

Ethics/Philosophy > Informed Consent > Hormonal Contraception Risk DisclosureContraception/Comparison > Side Effects > Comprehensive Risk OverviewBody Literacy > Women's Health Advocacy > Prescribing Transparency

The State of the Science of Natural Family Planning Fifty Years after Humane Vitae: A Report from NFP Scientists' Meeting Held at the US Conference of Catholic Bishops, April 4, 2018

Manhart MD et al., 2018 The Linacre Quarterly

A one-day meeting of physicians, professional nurses, and scientists actively involved in Natural Family Planning (NFP) research was held to review the state of the science of NFP and consider future ...

Fertility Awareness > Research Review > NFP Science State AssessmentRRM Methods > Method Comparison > Modern NFP EffectivenessResearch Methodology > Expert Consensus > Future Research Priorities

Bioethical and Moral Perspectives in Human Reproductive Medicine

Turner JV et al., 2018 The Linacre Quarterly

A reductive reading of Humanae vitae seeks to limit its appeal to a ban on contraception. In truth, however, it offers a vision of human sexuality and conjugal love with broad and enduring relevance. ...

Ethics/Philosophy > Bioethics > Reproductive Medicine Moral FrameworkEthics/Philosophy > Catholic Teaching > Humanae Vitae Broad VisionInfertility > Treatment Ethics > Assisted Reproduction Moral Analysis

Beyond fertility: polycystic ovary syndrome and long-term health

Cooney LG et al., 2018 Fertility and Sterility

Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with...

PCOS > Comorbidities > Metabolic and Cardiovascular RiskPCOS > Long-term Outcomes > Postmenopausal HealthPCOS > Comorbidities > Psychological Health

Modifiable life style factors and risk for incident endometriosis

Hemmert R et al., 2018 Paediatric and Perinatal Epidemiology

Background: Caffeine, alcohol, smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone-dependent gynaecologic disease risk, such as endometriosis; however, few...

Endometriosis > Risk Factors > Modifiable Lifestyle FactorsResearch Methodology > Prospective Cohort > ENDO StudyGeneral OB/GYN > Preventive Health > Lifestyle and Gynecologic Disease

The Ethics of Interstitial and Cesarean Scar Ectopic Pregnancies: Four Case Studies and a Review of the Literature

Buskmiller C, 2018 The Linacre Quarterly

Catholic bioethicists have extensively addressed extrauterine tubal pregnancies, which represent the great majority of ectopic pregnancies. However, additional management options have been developed f...

Pregnancy > Ectopic Pregnancy > Interstitial and Cesarean Scar TypesEthics/Philosophy > Catholic Bioethics > Ectopic Pregnancy ManagementSurgery > Gynecologic Surgery > Non-Tubal Ectopic Intervention

Metabolic syndrome in women with polycystic ovary syndrome

Chandrasekaran S et al., 2018 The Obstetrician & Gynaecologist

Key content The risk factors for metabolic syndrome include central obesity, hypertension, atherogenic dyslipidaemia and insulin resistance. Metabolic syndrome affects 33% of women with polycystic ova...

PCOS > Comorbidities > Metabolic SyndromePCOS > Screening > Cardiometabolic Risk AssessmentPCOS > Management > Lifestyle Modification

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization

Toljan K et al., 2018 Open Access Medical Sciences (Basel, Switzerland)

Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 ...

Diagnostics > Pharmacotherapy > Low-Dose Naltrexone Therapeutic ReviewGeneral OB/GYN > Pain Management > Opioid Antagonist TherapyResearch Methodology > Narrative Review > Off-Label Drug Applications

Association of oral contraceptive use with suicidal behavior among representative Korean population: Results from Korea National Health and Nutrition Examination Survey (2007-2016)

Jung SJ et al., 2018 Journal of Affective Disorders

Introduction: The association of suicide with the use of oral contraceptives (OC) is unknown in the Asian population. We aimed to evaluate the association of OC use and suicidal behavior in a national...

Contraception/Comparison > Oral Contraceptives > Mental Health Side EffectsContraception/Comparison > Oral Contraceptives > Suicidality RiskResearch Methodology > Observational Studies > Cross-Sectional Survey

The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions

Munro MG et al., 2018 Open Access International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics

Background: The International Federation of Gynecology and Obstetrics (FIGO) systems for nomenclature of symptoms of normal and abnormal uterine bleeding (AUB) in the reproductive years (FIGO AUB Syst...

Menstrual Cycle > Abnormal Uterine Bleeding > Classification SystemsGeneral OB/GYN > Clinical Guidelines > FIGO StandardsDiagnostics > Classification > Abnormal Uterine Bleeding

Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF

Boyle PC et al., 2018 Open Access Frontiers in Medicine

Objectives: To determine the live birth rate for patients who chose to undergo treatment with Restorative Reproductive Medicine (RRM) after previous IVF (includes ICSI). To look at birth outcomes with...

NaProTECHNOLOGY > Clinical Outcomes > Post-IVF RRM TreatmentRRM Methods > Treatment Effectiveness > Live Birth RatesInfertility > Treatment Comparison > RRM vs IVF Outcomes

Effectiveness of Fertility Awareness-Based Methods for Pregnancy Prevention: A Systematic Review

Peragallo Urrutia R et al., 2018 Obstetrics and Gynecology

OBJECTIVE: To summarize best available prospective data on typical and perfect use effectiveness of fertility awareness-based methods for avoiding pregnancy. DATA SOURCES: We conducted a systematic r...

Fertility Awareness > Effectiveness > Pregnancy Prevention RatesFertility Awareness > Methods Comparison > Systematic ReviewResearch Methodology > Systematic Review > Contraceptive Effectiveness

Current Medical Research: Summer/Fall 2017

Fehring RJ et al., 2018 The Linacre Quarterly

This issue of Current Medical Research (CMR) includes studies that provide evidence that use of natural family planning (NFP) can be helpful for subfertile couples wishing to achieve a pregnancy, the ...

Fertility Awareness > Research Review > Quarterly Evidence SummaryRRM Methods > Clinical Evidence > NFP Subfertility ApplicationsPostpartum > Natural Family Planning > Breastfeeding Method Effectiveness

Photobiomodulation: lasers vs. light emitting diodes?

Heiskanen V et al., 2018 Open Access Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology

Photobiomodulation (PBM) is a treatment method based on research findings showing that irradiation with certain wavelengths of red or near-infrared light has been shown to produce a range of physiolog...

Diagnostics > Photobiomodulation > Laser vs LED Therapy ComparisonResearch Methodology > Narrative Review > Light-Based TherapeuticsGeneral OB/GYN > Complementary Therapy > Photobiomodulation Applications

Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients

Tomioka RB et al., 2018 Clinical Rheumatology

To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy contro...

Menstrual Cycle > Ovulatory Disturbances > Luteinized Unruptured Follicle SyndromeReproductive Endocrinology > Medication Effects > NSAIDs and OvulationDiagnostics > Ultrasound Monitoring > Follicular Development and Ovulation

Insulin Sensitivity and Testicular Function in a Cohort of Adult Males Suspected of Being Insulin-Resistant

Contreras PH et al., 2018 Open Access Frontiers in Medicine

A cohort of 141 males (18-80 yo, 42.9 ± 12.9) strongly suspected of being Insulin Resistant (IR) was prospectively studied by determining their insulin sensitivity (Pancreatic Suppression Test, PST) a...

Andrology > Hormonal Assessment > Insulin Resistance and Testicular FunctionReproductive Endocrinology > Metabolic-Reproductive Axis > Male Insulin SensitivityInfertility > Male Factor > Metabolic Syndrome Hormonal Effects

Current clinical applications of platelet-rich plasma in various gynecological disorders: An appraisal of theory and practice

Dawood AS et al., 2018 Open Access Clinical and Experimental Reproductive Medicine

The purpose of this paper is to review the current clinical uses of platelet-rich plasma (PRP) in the field of gynecology. All relevant articles published from January 2000 to December 2017 were revie...

Infertility > Treatment Innovation > Platelet-Rich Plasma in GynecologyReproductive Endocrinology > Endometrial Regeneration > PRP TherapyResearch Methodology > Narrative Review > PRP Clinical Applications

Current Medical Research: Winter/Spring 2017

Fehring RJ et al., 2018 The Linacre Quarterly
Fertility Awareness > Research Review > Quarterly Evidence SummaryRRM Methods > Clinical Evidence > Method Comparison UpdatesResearch Methodology > Literature Review > Reproductive Health Digest

Self-Monitoring of Fertility Hormones: A New Era for Natural Family Planning?

Blackwell L et al., 2018 The Linacre Quarterly

Natural family planning (NFP) methods have served many generations well, and in particular, the symptothermal or symptohormonal methods. The comparison of daily mucus and temperature records for indiv...

Fertility Awareness > Technology > Home Fertility Hormone MonitoringRRM Methods > Biomarker Monitoring > Urinary Hormone Self-TestingDiagnostics > Ovulation Testing > Quantitative Home Immunoassay

Progesterone for treatment of symptomatic menopausal women

Prior JC, 2018 Climacteric : the Journal of the International Menopause Society

This review's purpose is to highlight evidence that oral micronized progesterone (progesterone) is effective for hot flushes and night sweats (vasomotor symptoms, VMS), improves sleep and is likely sa...

Perimenopause/Menopause > Treatment > Progesterone TherapyReproductive Endocrinology > Progesterone > Vasomotor Symptom ManagementPerimenopause/Menopause > Safety > Hormone Therapy Breast Cancer Risk

Progesterone for the prevention and treatment of osteoporosis in women

Prior JC, 2018 Open Access Climacteric : the Journal of the International Menopause Society

Estradiol (E2) is women's dominant 'bone hormone' since it is essential for development of adolescent peak bone mineral density (BMD) and physiological levels prevent the rapid (3-week) bone resorptio...

Bone Health > Osteoporosis Prevention > Progesterone TherapyReproductive Endocrinology > Progesterone > Bone FormationMenstrual Cycle > Ovulatory Disturbances > Bone Mineral Density Impact

Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles

Kim K et al., 2018 The British journal of nutrition

Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesised that low intakes of minerals would be asso...

Menstrual Cycle > Nutrition > Dietary Minerals and Ovulatory FunctionReproductive Endocrinology > Hormonal Balance > Micronutrient InfluenceInfertility > Modifiable Factors > Dietary Mineral Deficiency

A prospective study of physical activity and fecundability in women with a history of pregnancy loss

Russo LM et al., 2018 Open Access Human reproduction (Oxford, England)

Study Question: Is physical activity (PA) associated with fecundability in women with a history of prior pregnancy loss? Summary Answer: Higher fecundability was related to walking among overweight/o...

Infertility > Lifestyle Factors > Physical Activity and FecundabilityResearch Methodology > Prospective Cohort > EAGeR Trial Secondary AnalysisPregnancy > Preconception Health > Exercise and Conception Rates

Vertebral Fractures and Morphometric Deformities

Brian C Lentle et al., 2018 J Bone Miner Res

To the Editor: We read with interest the editorial by Cummings and Eastell,1 A History of Pivotal Advances in Clinical Research in Bone and Mineral Diseases, published in a recent issue of the JBMR. I...

Bone Health > Fracture Diagnosis > Vertebral Morphometry MethodsDiagnostics > Imaging > Vertebral Fracture AssessmentReproductive Endocrinology > Bone Health > Osteoporotic Fracture Classification

Hormonal Predictors of Abnormal Luteal Phases in Normally Cycling Women

Abdulla SH et al., 2018 Open Access Frontiers in Public Health

Objective: Explore potential relationships between preovulatory, periovulatory, and luteal-phase characteristics in normally cycling women. Design: Observational study. Setting: Eight European natural...

Reproductive Endocrinology > Luteal Phase > Hormonal Predictors of DeficiencyMenstrual Cycle > Ovulatory Function > Preovulatory-Luteal Phase RelationshipsRRM Methods > Biomarker Monitoring > Cycle Hormone Pattern Analysis

Steroid Hormones and Their Action in Women's Brains: The Importance of Hormonal Balance

Del Río JP et al., 2018 Open Access Frontiers in Public Health

Sex hormones significantly impact women's lives. Throughout the different stages of life, from menarche to menopause and all stages in between, women experience dramatic fluctuations in the levels of ...

Reproductive Endocrinology > Neuroendocrinology > Steroid Hormones and BrainMenstrual Cycle > Hormonal Influences > Mood and Cognitive FunctionPerimenopause/Menopause > Neuropsychiatric Effects > Hormonal Transition

Women's Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)

Wong EMM et al., 2018 Open Access International Journal of Environmental Research and Public Health

Women's hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone ...

Perimenopause/Menopause > Vasomotor Symptoms > Bone Density Loss AssociationBone Health > Perimenopause > Night Sweats and BMD ChangesResearch Methodology > Prospective Cohort > Canadian Multicentre Osteoporosis

Combined hormonal contraceptives use and bone mineral density changes in adolescent and young women in a prospective population-based Canada-wide observational study

Brajic TS et al., 2018 Journal of Musculoskeletal & Neuronal Interactions

Objectives: To assess combined hormonal contraceptives (CHC) use and adolescent women's peak areal bone mineral density (BMD) accrual. Methods: We enrolled 527 randomly selected women across Canada (...

Bone Health > Contraception Impact > Population-Based Prospective EvidenceContraception/Comparison > Combined Hormonal > Skeletal Health OutcomesResearch Methodology > Prospective Cohort > Canadian Multicentre Study