Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in  Premature Menopause

Sfakianoudis K; Simopoulou M; Nitsos N; Rapani A; Pappas A; Pantou A; Koutsilieris M; Pantos K; Chronopoulou M; Deligeoroglou E

doi:10.3390/jcm8010001

Assisted Reproduction · Add-Ons and Adjuncts

Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

Sfakianoudis K, Simopoulou M, Nitsos N, Rapani A, Pappas A, Pantou A, Koutsilieris M, Pantos K, Chronopoulou M, Deligeoroglou E

Published December 20, 2018 Journal of Clinical Medicine, 8(1), E1

DOI 10.3390/jcm8010001 PMID 30577435 PMC PMC6352170

Abstract

This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient's follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation.

Topics

Assisted Reproduction › Add-Ons and Adjuncts › Adjunct Evidence Base · Reproductive Endocrinology › Ovarian Hormones › Estrogen · Longevity and Reproductive Aging › Reproductive Aging › Ovarian Aging

Konstantinos Sfakianoudis, Athanasios Pappas, Agni Pantou, Michael Koutsilieris, Konstantinos Pantos, Margarita Chronopoulou, Efthymios Deligeoroglou, Nikolaos Nitsos, Anna Rapani, Mara Simopoulou

K Sfakianoudis, A Pappas, A Pantou, Mike Koutsilieris, M Koutsilieris, K Pantos, M Chronopoulou, E Deligeoroglou, N Nitsos, A Rapani, M Simopoulou

PMID 30577435 30577435 DOI 10.3390/jcm8010001 10.3390/jcm8010001 Sfakianoudis et al. 2018, Sfakianoudis 2018

Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

Abstract

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