Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions

Fredericks CM; Kotry I; Holtz G; Askalani AH; Serour GI

doi:10.1016/0002-9378(86)90304-2

Reproductive Surgery Adhesion Prevention

Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions

Fredericks CM, Kotry I, Holtz G, Askalani AH, Serour GI

Published September 1986 American Journal of Obstetrics and Gynecology, 155(3), 667-670

DOI 10.1016/0002-9378(86)90304-2 PMID 2428251

Abstract

With the use of a rabbit surgical model, the ability of 1%, 2%, and 3% solutions of sodium carboxymethylcellulose to reduce postoperative uterine adhesions was determined. At all concentrations sodium carboxymethylcellulose was more effective than either 32% dextran 70 or heparinized lactated Ringer's solution. Neither the dextran nor Ringer's solution had a significant (p less than or equal to 0.05) effect. The beneficial effects of sodium carboxymethylcellulose were closely dose-dependent (correlation coefficient 0.97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety.

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12 min read

Topics

Reproductive Surgery

Adhesion Prevention Barrier Agents

Reproductive Surgery › Adhesion Prevention › Barrier Agents

PMID 2428251 2428251 DOI 10.1016/0002-9378(86)90304-2 10.1016/0002-9378(86)90304-2 Fredericks et al. 1986, Fredericks 1986

Keywords

Animals, Autopsy, Carboxymethylcellulose Sodium/administration & Dosage/therapeutic Use, Dextrans/administration & Dosage, Dose-Response Relationship, Drug, Female, Isotonic Solutions/administration & Dosage, Methylcellulose/analogs & Derivatives, Microsurgery/methods, Peritoneal Diseases/prevention & Control, Postoperative Complications/prevention & Control, Rabbits, Ringer's Lactate, Solutions, Tissue Adhesions/prevention & Control, Uterus/surgery, Dextrans, Isotonic Solutions, Ringer's Lactate, Solutions, Methylcellulose, Carboxymethylcellulose Sodium

Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions

Abstract

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