The purpose of this study was to critically review published studies regarding sensitivity, specificity, and positive and negative predictive values of antenatal tests to diagnose chorioamnionitis or fetal-neonatal sepsis in preterm premature rupture of the membranes. A Medline Data-Base computer program search from 1980 to 1988 identified 39 studies, 23 of which were accepted after independent review with preset criteria. An ideal test to predict chorioamnionitis or neonatal sepsis was not found. The low success rate for amniocentesis and the need for repeat taps preclude the acceptance of tests on the basis of amniotic fluid. Single, small studies, the precision of which has never been tested, show good indices for repeatedly increased serum levels of C-reactive protein (greater than 20 mg/L), a high level of C-reactive protein greater than 40 mg/L, or a day-to-day coefficient of variation for C-reactive protein of greater than 30% in the prediction of histologic or clinical chorioamnionitis. Ultrasonographic observation of fetal activity, if published study results are confirmed, may be of value to predict amniotic fluid bacterial colonization.
PMID 2180308 2180308 DOI 10.1016/0002-9378(90)91016-6 10.1016/0002-9378(90)91016-6 Ohlsson et al. 1990, Ohlsson 1990
Cite this article
Ohlsson, A., & Wang, E. (1990). An analysis of antenatal tests to detect infection in preterm premature rupture of the membranes. American journal of obstetrics and gynecology, 162(3), 809-818. https://doi.org/10.1016/0002-9378(90)91016-6
Ohlsson A, Wang E. An analysis of antenatal tests to detect infection in preterm premature rupture of the membranes. Am J Obstet Gynecol. 1990;162(3):809-818. doi:10.1016/0002-9378(90)91016-6
Ohlsson, A., and E. Wang. "An analysis of antenatal tests to detect infection in preterm premature rupture of the membranes." American journal of obstetrics and gynecology, vol. 162, no. 3, 1990, pp. 809-818.
Keywords
Amniotic Fluid/microbiology, Female, Fetal Membranes, Premature Rupture/diagnosis, Humans, Infant, Newborn, Infant, Premature, Infections/diagnosis, Predictive Value of Tests, Pregnancy/blood, Prenatal Diagnosis/methods, Sensitivity and Specificity, Ultrasonography
Humphries LA et al., 2016·American Journal of Obstetrics and Gynecology
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Physiologic effectiveness is the measure of protection against unwanted pregnancy afforded by a specific contraceptive method under ideal conditions ie, used consistently and according to instructions-without omissions, or errors of technique. Such ideal conditions are rarely present. Even when they are, it is not practicable to observe and verify them. Physiologic effectiveness, although not accessible to direct measurement, is by definition higher than the observed clinical effectiveness of the same method in the hands of the most …
Restorative Care and Assisted Reproduction · Outcome Comparisons
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