More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

Eugenia Pittaluga; Graziella Costa; Ewa Krasnowska; Roberto Brunelli; Thomas Lundeberg; Maria Grazia Porpora; Daniela Santucci; Tiziana Parasassi

doi:10.1016/j.fertnstert.2010.06.038

Endometriosis Medical Management

More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

Pittaluga E, Costa G, Krasnowska E, Brunelli R, Lundeberg T, Porpora MG, Santucci D, Parasassi T

Published December 2010 Fertility and sterility

DOI 10.1016/j.fertnstert.2010.06.038 PMID 20655527

Abstract

N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment.

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Endometriosis Explained: Diagnosis, Excision Surgery, and the RRM Approach

Endometriosis is a chronic inflammatory disease that drives pain, organ dysfunction, and infertility. How RRM-trained clinicians diagnose and treat it through excision surgery, cycle charting, and longitudinal care.

22 min read

Topics

Endometriosis › Medical Management › Hormonal Suppression Outcomes · Therapeutics › Supplements and Botanicals › Antioxidant Supplements · General Gynecology › Clinical Practice › Pharmacology

Eugenia Pittaluga, Graziella Costa, Ewa Krasnowska, Roberto Brunelli, Thomas Lundeberg, Maria Grazia Porpora, Daniela Santucci, Tiziana Parasassi

E Pittaluga, G Costa, E Krasnowska, R Brunelli, Tom Lundeberg, T Lundeberg, M Porpora, D Santucci, T Parasassi

PMID 20655527 20655527 DOI 10.1016/j.fertnstert.2010.06.038 10.1016/j.fertnstert.2010.06.038 Pittaluga et al. 2010, Pittaluga 2010

More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

Abstract

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