Spontaneous pregnancy following intra-ovarian platelet-rich plasma administration in poor ovarian responders according to the POSEIDON criteria: A cross-sectional study
Sanuie Farimani M,Amiri K,Anvari Aliabad R
Published August 2025International journal of reproductive biomedicine, 23(8), 627-636
Sanuie Farimani, M., Amiri, K., & Anvari Aliabad, R. (2025). Spontaneous pregnancy following intra-ovarian platelet-rich plasma administration in poor ovarian responders according to the POSEIDON criteria: A cross-sectional study. International journal of reproductive biomedicine, 23(8), 627-636. https://doi.org/10.18502/ijrm.v23i8.19811
Sanuie Farimani M, Amiri K, Anvari Aliabad R. Spontaneous pregnancy following intra-ovarian platelet-rich plasma administration in poor ovarian responders according to the POSEIDON criteria: A cross-sectional study. International journal of reproductive biomedicine. 2025;23(8):627-636. doi:10.18502/ijrm.v23i8.19811
Sanuie Farimani, Marzie, et al. "Spontaneous pregnancy following intra-ovarian platelet-rich plasma administration in poor ovarian responders according to the POSEIDON criteria: A cross-sectional study." International journal of reproductive biomedicine, vol. 23, no. 8, 2025, pp. 627-636.
For EndNote, Zotero or Mendeley:
Open access
No open license is recorded for this paper. Reuse terms are set by the publisher.
Open Access
Free full text on PubMed Central (PMC12477538)
RRM Academy Synopsis
Spontaneous pregnancy followed ovarian PRP in 8.39% of poor responders
Spontaneous pregnancy followed ovarian platelet-rich plasma in 8.39% of poor responders. This cross-sectional study took place at one clinic in Iran. Researchers included 596 women with poor ovarian response who finished two years of follow-up. Fifty of them conceived. Researchers sorted 42 of these women, the ones with complete data, into POSEIDON groups.
Key Findings
Among the 42 women analyzed, the median age was 37.00 years [32.00–40.00] and the median infertility duration was 3.00 years [1.5–5.00].
Women's age, spouse age, body mass index, anti-Müllerian hormone and follicle/oocyte count differed significantly among POSEIDON groups (body mass index p = 0.039; follicle/oocyte count p = 0.022).
Of 1548 women with poor ovarian response who received intra-ovarian platelet-rich plasma (IO-PRP), 596 (38.50%) completed 2 years of follow-up, and 50 of them (8.39%) had a spontaneous pregnancy.
Eight pregnancies were excluded for missing data. Of the 42 analyzed, POSEIDON group 4 had 17 women, group 3 had 9, and groups 1 and 2 had 8 each.
Interpretation
This cross-sectional study reviewed clinic records. The women had poor ovarian response and got intra-ovarian platelet-rich plasma in Hamadan, Iran. Among the 42 women who conceived and had complete data, POSEIDON group 4 was the largest. Group 3 came next. Groups 1 and 2 were equal and smallest. The authors note the small sample size as a limitation. They call for prospective cohort studies to build on these findings.
RRM Context
Poor ovarian response is a label based partly on how the ovaries reacted to stimulation drugs in past IVF cycles. Restorative reproductive medicine treats a low ovarian reserve result as the start of a question about cause. The paper reports the type of infertility: primary, secondary, or combined. The paper also records the male partners' age and semen analysis results, keeping the couple's evaluation in view.
Our editorial summary of this paper, not the article's abstract.
Abstract
Background
Female infertility, especially in those individuals with poor ovarian response (POR), is a challenge in the field of infertility and sterility. Recently, intra-ovarian platelet-rich plasma (IO-PRP) administration has been suggested as a possible co-treatment.
Objective
This study aimed to investigate the biodemographic characteristics of individuals who experienced spontaneous pregnancy following IO-PRP.
Materials and Methods
In this cross-sectional study, out of 1548 women diagnosed with POR who underwent IO-PRP, 596 individuals who completed their 2-yr follow-up period, were included. Different types of demographic and pre-intervention laboratory data (blood levels of anti-Müllerian hormone, luteinizing hormone, follicle-stimulating hormone, estradiol, prolactin, and their spouses' sperm analysis results) were collected from the files. Each individual was classified into a certain group according to the POSEIDON criteria, and their data were compared.
Results
The results showed that 50 (8.39%) spontaneous pregnancies were observed. However, 8 were excluded from further analyses due to missing data in their critical variables. The most prevalent POSEIDON group was 4, with a prevalence of 17/42 (40.47%). Among the POSEIDON groups, covariates including the age of the individuals and their spouses, body mass index, anti-Müllerian hormone, and antral follicle/oocytes count following the latest IO-PRP significantly differed (p < 0.001, p < 0.001, p = 0.039, p < 0.001, and p = 0.022, respectively).
Conclusion
The spontaneous pregnancy rate following IO-PRP among women with POR was low. However, significant differences in biodemographic and hormonal characteristics were observed between the groups with and without spontaneous pregnancy which could be useful in leading future studies on this subject.
