Mierzyński, R., Dłuski, D., Nowakowski, Ł., Poniedziałek-Czajkowska, E., & Leszczyńska-Gorzelak, B. (2018). Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus. BioMed research international. https://doi.org/10.1155/2018/7154216
Mierzyński R, Dłuski D, Nowakowski Ł, Poniedziałek-Czajkowska E, Leszczyńska-Gorzelak B. Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus. BioMed research international. 2018. doi:10.1155/2018/7154216
Mierzyński, Radzisław, et al. "Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus." BioMed research international, 2018.
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RRM Academy Synopsis
Lower omentin levels linked to preterm birth in gestational diabetes
Lower omentin levels were linked to spontaneous preterm birth in women with gestational diabetes. The retrospective study compared 105 women with the condition and 55 women with healthy pregnancies. Adiponectin showed no significant link with preterm birth in regression analysis. Both are hormones made mainly by fat tissue.
Key Findings
Median adiponectin and omentin levels were significantly lower in all three gestational diabetes groups (63, 23 and 19 women) than in 55 women with healthy pregnancies (p<0.01).
Adiponectin and omentin levels did not differ significantly between women with gestational diabetes who delivered at term, had threatened preterm labor, or had spontaneous preterm birth. The preterm group trended lower.
In univariable logistic regression, higher omentin was associated with lower odds of spontaneous preterm birth against healthy pregnancies (p=0.0006) and against women with gestational diabetes (p=0.017).
Adiponectin showed no significant association with preterm birth in the same regression model.
Adiponectin and omentin correlated strongly in every group (R=0.705 to R=0.824, p<0.001).
Interpretation
This retrospective study analyzed stored blood samples drawn at 24 to 28 weeks at the Medical University of Lublin. The spontaneous preterm birth group had 19 women. The threatened preterm labor group delivered at term. The regression compared groups within one sample and found an association between lower omentin and preterm birth. All participants were Caucasian, and the authors say the findings might not apply to other populations. They call the sample relatively small and possibly underpowered, and they state that larger studies are needed.
RRM Context
The authors list IVF among other factors linked to preterm birth, along with extreme maternal age. They report that adiponectin and omentin, hormones made mainly by fat tissue, were lower when body mass index was higher, in every group. Restorative reproductive medicine treats metabolic health as part of reproductive health. It looks for causes before conception.
Our editorial summary of this paper, not the article's abstract.
Abstract
Objective
The aim of this study was to determine any changes in adiponectin and omentin levels in GDM patients who delivered at term and preterm and to evaluate whether adipokines can be useful as a clinical biomarker to predict subsequent preterm delivery.
Patients and Methods
The levels of adiponectin and omentin were measured in four groups: (1) women with GDM who delivered at term (n=63); (2) women with GDM who had the symptoms of threatened preterm labor and delivered at term (n=23); (3) women with GDM and spontaneous preterm birth (before 37 completed weeks of gestation) (n=19); (4) women with physiological pregnancy (n=55).
Results
In comparison with control group the median adiponectin concentrations were significantly lower in all GDM groups (10737 versus 8879; 7057; 6253 ng/ml, respectively; p<0.01). The median omentin concentrations were also significantly lower in all GDM groups in comparison with control group (469 versus 432; 357; 308 ng/ml, respectively; p<0.01). No significant differences in adiponectin and omentin levels between the GDM, preterm labor, and preterm birth groups were observed. However, there was a trend towards lower adiponectin and omentin levels in preterm birth group. The strong correlations between adiponectin and omentin levels were observed in all groups (R=0.801, p<0.001; R=0.824, p<0.001; R=0.705, p<0.001; R=0.764, respectively; p<0.001). In the univariable logistic regression model, significant correlation between omentin concentrations and preterm birth occurrence was found.
Conclusions
Our findings suggest that omentin-1, rather than adiponectin, could be useful as a predictor of preterm birth in patients with gestational diabetes mellitus.
