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Therapeutics · Hormonal Agents

Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia

Lei B, Mace B, Dawson HN, Warner DS, Laskowitz DT, James ML

Published July 31, 2014 PLoS One
DOI 10.1371/journal.pone.0103969 PMID 25080336 PMC PMC4117574

Abstract

Female sex is associated with improved outcome in experimental brain injury models, such as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female gonadal steroids may be neuroprotective. A mechanism for this may involve modulation of post-injury neuroinflammation. As the resident immunomodulatory cells in central nervous system, microglia are activated during acute brain injury and produce inflammatory mediators which contribute to secondary injury including proinflammatory cytokines, and nitric oxide. In this study, the authors examined the anti-inflammatory effects of progesterone on lipopolysaccharide-stimulated BV-2 microglia, characterizing progesterone's suppression of microglial inflammatory mediator production.

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Therapeutics › Hormonal Agents › Progesterone and Progestins
PMID 25080336 25080336 DOI 10.1371/journal.pone.0103969 10.1371/journal.pone.0103969 Lei et al. 2014, Lei 2014

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