assisted-reproduction/registries-and-reporting/national-registry-data
Kupka MS et al., 2014 · Human reproduction (Oxford, England)
Jul 27. Assisted reproductive technology in Europe, 2010: results generated from European registers by ESHRE†. Kupka MS(1), Ferraretti AP(2), de Mouzon J(2), Erb K(2), D'Hooghe T(2), Castilla JA(2), Calhaz-Jorge C(2), De Geyter C(2), Goossens V(2); European IVF-Monitoring Consortium, for the European Society of Human Reproduction and Embryology. Collaborators: Grunwald KM, Neulen J, Rösing B, Weisenborn U, Rau R, Schro B, Eid R, Hiller K-, Bauer T, Kraus H, Bayreuth K, Todorow S, Struller D, Etien C, Temme DH, Kentenich H, Siemann A, Stief G, Tandler-Schneider A, Remberg B, Tewordt S, Bloechle M, Marr S, Awwadeh H, Mutz A, Roth B, Kadgien C, Hannen R, Stoll CF, Jantke A, Spindeldreher S, Stegelmann A, Nowshari M, Sydow P, Peet DJ, Sydow C, Bergmann-Hensel U, Pfüller B, Bartley J, Scheiber I, Schmiady H, Ebert PA, Völklein K, Harms B, Baban N, Hilland U, Giesner Y, van der Ven H, van der Ven K, Bohlen U, Montag M, Prietl G, Drost O, Schmidt EH, Stutterheim Av, Finger T, Meyer-Ströh S, Jogschies P, Geistert D, Shugair L, Lahl A, Chemnitz S, Gabert A, Bauer K, Saager G, Leyendecker G, Bilgicyildirim A, Inacker M, Kroiss HJ, Bernhardt E, Braüker A, Vornehm H, Wilhelm E, Dieterle S, Neuer A, Greb R, Held HJ, Distler W, Keck G, Gouma E, Kru JS, Hess A, Mikat-Drozdzynski B, Schanz A, Hirchenhain J, Scholtes M, Marx K, Kisler S, Behler M, Pfeiffer S, Hubert P, Emde T, Yildirim-Assaf S, Frauena, Hamori M, Behrens R, Hammel A, Van Uem J, Beckmann MW, Müller A, Dittrich R, Katzorke T, Propping D, Wohlers S, Bielfeld P, Costea J, Wiegratz I, Merz E, Siebzehnru E, Weidner A, Weitzell, Thiemann, Wetzka, Geisthövel F, Friebel S, Hanjalic-Beck A, Zahradnik HP, Ina Walter-Göbel, Fiseler K, Hinney B, Michelmann HW, Moltrecht R, Hübner S, Welcker T, Sakin-Kaindl F, Mittmann S, Schulzeck P, Tobler M, Rostek J, Tigges J, Friol K, Gnoth C, Behre HM, Kaltwaser P, Seliger E, Horn, Michel u Partner, Bispink, Horn, Michel, Gohmann, Aytekin, Acar-Nosit, Kocak S, List P, Weidner U, Fischer R, Martina, Müseler-Albers, Arendt HP, Bühler K, Schill T, Schippert, Basler, Parta-Kehry W, Parta S, Tesarz F, Seehaus D, Tho C, Strowitzki T, Toth B, Algermissen, Justus, Wilke, Graf, Hildesheim, Fritzsche H, Reiher JP, Hoffmann A, Weiss J, Hoppe I, Wetzel V, Tetens F, Schlüter G, Willi MJ, Schmidt O, Hinrichsen M, Felberbaum R, Gerhard OA, Hiltensberger D, Kousehlar M, von Otte S, Schulz V, Völckers M, Eckel H, Schmutzler A, Salmassi A, Brandenburg K, Bonhoff A, Carstensen A, Merzenich M, Palm S, Pu I, Dannhof M, Keck C, Foth D, Ko U, Rahimi G, Moers C, Orth I, Leer K, von der Burg W, Alexander H, Weber W, Hmeidan FA, Jogschies P, Shugair L, Geistert D, Lahl A, Gabert A, Bauer K, Saager G, Griesinger G, Schultze-Mosgau A, Diedrich K, Schmidt T, Schmidt C, Motzkus N, Nickel I, Richter E, Kleinstein J, Brössner A, Sütterlin M, Schaffelder R, St Bussen, Schüttler J, Gentili, Sc RS, Passuello V, Kölbl H, Emig R, Mettlin S, Hadji P, Wagner U, Ziller V, Buurman O, Dumschat M, Menkhaus R, Heidecker B, Döhmen G, Schalk T, Bogenhausen AR, Berg D, Lesoine B, Kupka MS, Papadopoulos P, Thaler CJ, von Schönfeldt V, Friese K, Lacher H, Puchta J, Michna S, Pauer HU, Fiedler K, von Hertwig I, Würfel W, Laubert I, Santjohanser C, Völker S, Meri O, Krüsmann J, Bollmann W, Brückner T, Noss U, Belkien L, Niehoff C, Kiesel, Kreimer M, Kliesch, Sudik R, Kissing-Pahl K, Beran J, Müller B, Munzer-Neuwinger B, Neuwinger J, Licht P, Manolopoulos K, Oldenburg T, Hennefründ J, Boppert H, Heeder M, Jibril S, Pohlig G, Coordes I, Schneider M, Pforzheim K, Peuten V, Boehm S, Lehnert M, Recklinghausen K, Seifert B, Bals-Pratsch M, Luckhaus J, Müller H, Busecke A, Bossow A, Thaele M, Happel L, Giebel A, Nassar N, Otte M, Fuchs U, Maleika F, Harrer S, B D, Trier P, Satari M, Wissenschaftspark JP, Göhring, Göhring U, Göhring I, Lawrenz B, Neunhoeffer E, Gagsteiger, Sterzik K, Strehler E, Hancke K, Seemann B, Isachenko E, Rosenbusch B, Wetzlar V, Hajimohammad A, Oels B, Schorsch M, Hahn T, Adasz G, Schilberz K, Frambach T, Bernar T, Mai R, Schmitt W, Mulfinger L. (1)ESHRE Central Office, Meerstraat 60, Grimbergen B-1852, Belgium mail@prof-kupka.de. (2)ESHRE Central Office, Meerstraat 60, Grimbergen B-1852, Belgium. The 14th European IVF--monitoring (EIM) report presents the results of medically assisted reproduction treatments including assisted reproductive technology (ART) cycles and intrauterine insemination (IUI) cycles initiated in Europe during 2010: are there changes in the trends compared with previous years? Despite some fluctuations in the number of countries reporting, the overall number of ART cycles has continued to increase year by year, and while pregnancy rates in 2010 remained similar to those reported in 2009, the number of transfers with multiple embryos (three or more) further declined. Since 1997, ART data in Europe have been collected and reported in 13 manuscripts, published in Human Reproduction. STUDY D
assisted-reproduction/registries-and-reporting/national-registry-data
Ferraretti AP et al., 2013 · Human reproduction (Oxford, England)
9. Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Ferraretti AP(1), Goossens V, Kupka M, Bhattacharya S, de Mouzon J, Castilla JA, Erb K, Korsak V, Nyboe Andersen A; European IVF-Monitoring (EIM) Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Collaborators: Strohmer H, Bogaerts K, Kyurkchiev S, Vrcic H, Pelekanos M, Rezabek K, Erb K, Gissler M, Royere D, Bühler K, Tarlatzis BC, Kosztolanyi G, Bjorgvinsson H, Mocanu E, Scaravelli G, Lokshin V, Arajs M, Gudleviciene Z, Lazarevski S, Moshin V, Simic TM, Hazekamp JT, Kurzawa R, Calhaz-Jorge C, Rugescu I, Korsak V, Radunovic N, Tomazevic T, Hernandez JH, Karlström PO, Weder M, Lambalk C, Veselovsky V, Baranowski R. (1)ESHRE Central Office, Grimbergen, Belgium. annapia.ferraretti @sismer.it The 13th European in vitro fertilization (IVF)-monitoring (EIM) report presents the results of treatments involving assisted reproductive technology (ART) initiated in Europe during 2009: are there any changes in the trends compared with previous years? Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year and, while pregnancy rates in 2009 remained similar to those reported in 2008, the number of transfers with multiple embryos (3+) and the multiple delivery rates declined. Since 1997, ART data in Europe have been collected and reported in 12 manuscripts, published in Human Reproduction. STUDY DESIGN, SIZE, Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE); cycles started between 1st January and 31st December are collected on a yearly basis; the data are collected by the National Registers, when existing, or on a voluntary basis. PARTICIPANTS/MATERIALS SETTING, From 34 countries (-2 compared with 2008), 1005 clinics reported 537 463 treatment cycles including: IVF (135 621), intracytoplasmic sperm injection (ICSI, 266 084), frozen embryo replacement (FER, 104 153), egg donation (ED, 21 604), in vitro maturation (IVM, 1334), preimplantation genetic diagnosis/screening (PGD/PGS, 4389) and frozen oocyte replacements (FOR, 4278). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor (IUI-D) semen were reported from 21 and 18 countries, respectively. A total of 162 843 IUI-H (+12.7%) and 29 235 IUI-D (+17.3%) cycles were included. Data available from each country are presented in the tables; total values (as numbers and percentages) refer to those countries where all data have been reported. MAIN In 21 countries where all clinics reported to the ART register, a total of 399 020 ART cycles were performed in a population of 373.8 million, corresponding to 1067 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 28.9 and 32.9%, respectively and for ICSI, the corresponding rates were 28.7 and 32.0%. In FER cycles, the pregnancy rate per thawing was 20.9%; in ED cycles, the pregnancy rate per transfer was 42.3%. The delivery rate after IUI-H was 8.3 and 13.4% after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 24.2, 57.7, 16.9 and 1.2%, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (combined) were 79.8, 19.4 and 0.8%, respectively, resulting in a total multiple delivery rate of 20.2%, compared with 21.7% in 2008, 22.3% in 2007, 20.8% in 2006 and 21.8% in 2005. In FER cycles, the multiple delivery rate was 13.0% (12.7% twins and 0.3% triplets). Twin and triplet delivery rates associated with IUI cycles were 10.4/0.7% and 10.3/0.5%, following treatment with husband and donor semen, respectively. LIMITATIONS, The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution. The 13th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than half a million of cycles reported in 2009. The use of ICSI has reached a plateau. Pregnancy and delivery rates after IVF and ICSI remained relatively stable compared with 2008 and 2007. The number of multiple embryo transfers (3+ embryos) and the multiple delivery rate have shown a clear decline.
assisted-reproduction/registries-and-reporting/national-registry-data
Ferraretti AP et al., 2012 · Human reproduction (Oxford, England)
10. Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE. Ferraretti AP(1), Goossens V, de Mouzon J, Bhattacharya S, Castilla JA, Korsak V, Kupka M, Nygren KG, Nyboe Andersen A; European IVF-monitoring (EIM); Consortium for European Society of Human Reproduction and Embryology (ESHRE). (1)ESHRE Central Office, Meerstraat 60, B-1852 Grimbergen, Belgium. annapia.ferraretti@sismer.it This 12th European IVF-monitoring (EIM) report presents the results of treatments involving assisted reproductive technology (ART) initiated in Europe during 2008. From 36 countries (3 more compared with 2007), 1051 clinics reported 532 260 treatment cycles including: IVF (124 539), ICSI (280 552), frozen embryo replacements (FER, 97 120), egg donation (ED, 13 609), in vitro maturation (IVM, 562), preimplantation genetic diagnosis/screening (PGD/PGS, 2875) and frozen oocyte replacements (FOR, 4080). Overall, this represents a 7.9% increase in the activity since 2007, which is mainly related to an increase in cycles from almost all registers and only partially to the new countries entering EIM (Estonia, Kazakhstan, Moldova and Romania, 5480 cycles in total). European data on intrauterine insemination using husband/partner's (IUI-H) and donor (IUI-D) semen were reported from 27 and 21 countries, respectively. A total of 144 509 IUI-H (+1.5%) and 24 960 IUI-D (-4.3%) cycles were included. In 19 countries where all clinics reported to the ART register, a total of 350 143 ART cycles were performed in a population of 369.8 million, corresponding to 947 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 28.5 and 32.5%, respectively, and for ICSI the corresponding rates were 28.7 and 31.9%. In FER cycles, the pregnancy rate per thawing was 19.3%. The delivery rate after IUI was 9.1% for IUI-H and 13.8% for IUI-D. In IVF and ICSI cycles, one, two, three and four or more embryos were transferred in 22.4, 53.2, 22.3 and 2.1%, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (combined) were 78.3, 20.7 and 1.0%, respectively, resulting in a total multiple delivery rate of 21.7%, compared with 22.3% in 2007, 20.8% in 2006 and 21.8% in 2005. In FER cycles, the multiple delivery rate was 13.7% (13.4% twins and 0.3% triplets). In women undergoing IUI, twin and triplet deliveries occurred in 10.6% and 0.7% with IUI-H and in 9.4 and 0.3% with IUI-D, respectively. In comparison with previous years, there was an increase in the reported number of ART cycles in Europe. For the first time in 5 years, the pregnancy rates failed to show a year-on-year increase. Compared with 2007, the number of transfers of multiple embryos (3+) and a multiple delivery rate showed a marginal decline.