Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users

Lussana F, Zighetti ML, Bucciarelli P, Cugno M, Cattaneo M

doi:10.1016/j.thromres.2003.11.007

Thrombosis research, 112(1-2), 37-41, 2003

Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users

Lussana F, Zighetti ML, Bucciarelli P, Cugno M, Cattaneo M

Critical to restorative reproductive medicine

DOI10.1016/j.thromres.2003.11.007 PMID15013271

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Abstract

BACKGROUND AND

Objectives

To compare the levels of total homocysteine (tHcy), folate, vitamin B6 and B12, in women not using oral contraceptives (OC) vs. those using OC.

Materials and Methods

219 healthy women were enrolled in the study; 159 of them had not been using OC for at least 12 months prior to their enrollment, while 60 were on regular OC treatment.

Results

The median levels of vitamin B6 and B12 were significantly lower in OC users than in non-users (24.2 vs. 32.9 nmol/l, p=0.029; 278 vs. 429 ng/ml, p<0.001). There were no statistically significant differences in the levels of tHcy (fasting and post-methionine loading) and folate.

Conclusions

In our cross-sectional study, OC use was associated with low vitamin B6 and B12 levels. Since low vitamin B6 levels are independently associated with heightened risks for arterial and venous thromboembolism (TE), they could partly account for the increased TE risk of OC users.

PMID 15013271 15013271 DOI 10.1016/j.thromres.2003.11.007 10.1016/j.thromres.2003.11.007