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Comparison of the effect of two combinations of myo-inositol and D-chiro-inositol in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial

Mendoza N, Diaz-Ropero MP, Aragon M, Maldonado V, Llaneza P, Lorente J, Mendoza-Tesarik R, Maldonado-Lobon J, Olivares M, Fonolla J

Published August 2019 Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 35(8), 695-700
DOI 10.1080/09513590.2019.1576620 PMID 30880505

Abstract

The purpose of this study was to evaluate the effect of two doses of D-chiro-inositol (DCI) in combination with Myo-inositol (MYO) in women with PCOS undergoing ICSI. This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12 weeks. The study group (SG) was administered 550 mg of MYO + 150 mg of DCI twice daily; the control group (CG) was administered 550 mg of MYO + 13.8 mg of DCI twice daily. The participants comprised 60 women with PCOS undergoing ICSI. At baseline, no differences were found between the two groups regarding age, BMI, HOMA-IR or testosterone levels. The pregnancy and live birth rates were significantly higher in the SG than in the CG (65.5 vs. 25.9 and 55.2 vs. 14.8, respectively) [risk ratio (RR) = 0.4; 95%CI (0.2, 0.79); p = .003 and RR = 0.27; 95%CI (0.10, 0.70); p = .002 respectively]. The risk of ovarian hyperstimulation syndrome (OHSS) was lower in the SG (3.44 vs. 18.5%, p = .07). The combination of MYO-DCI at high doses of DCI improves the pregnancy rates and reduces the risk of OHSS in women with PCOS undergoing ICSI.

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Nicolas Mendoza, Maria Paz Diaz-Ropero, Miguel Aragon, Vicente Maldonado, Placido Llaneza, Juan Lorente, Raquel Mendoza-Tesarik, Jose Maldonado-Lobon, Monica Olivares, Juristo Fonolla
N Mendoza, M Diaz-Ropero, M Aragon, V Maldonado, P Llaneza, J Lorente, R Mendoza-Tesarik, J Maldonado-Lobon, M Olivares, J Fonolla
PMID 30880505 30880505 DOI 10.1080/09513590.2019.1576620 10.1080/09513590.2019.1576620 Mendoza et al. 2019, Mendoza 2019

Keywords

-chiro-inositol, ICSI, Myo-inositol, polycystic ovary syndrome, pregnancy rate

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