Lifestyle and Environment Nutrition and Metabolic Health
RRM Academy Synopsis
AMH rose after vitamin D in 51 women with diminished ovarian reserve
AMH levels rose after three months of vitamin D in 51 women with diminished ovarian reserve and low vitamin D. This before-and-after study ran at a clinic in Yasuj, Iran. Vitamin D levels rose too, over the same period. Weekly vitamin D tablets were the treatment tested here. Antral follicle count held steady for this group at the start.
Key Findings
- The study followed 51 women aged 18 to 40 with diminished ovarian reserve and vitamin D deficiency at a clinic in Yasuj, Iran, in 2018 to 2019.
- Blood vitamin D levels rose after 3 months of weekly vitamin D tablets (P < 0.001).
- Serum AMH rose over the same 3 months (P=0.02).
- After treatment, AMH showed no statistically significant difference between women under 35 and women over 35 (P = 0.13).
- Antral follicle count was reported before treatment only.
Interpretation
This before-and-after study followed 51 women with diminished ovarian reserve and low vitamin D, at a clinic in Yasuj, Iran. Vitamin D was linked with a rise in AMH over three months. The authors suggest vitamin D may raise AMH by acting on the AMH gene, without changing antral follicle count or ovarian reserve. The findings support larger studies of vitamin D in women with diminished ovarian reserve.
RRM Context
AMH is a blood marker of the follicle pool. Restorative reproductive medicine looks for the cause of a low marker, which can include diet and nutrients like vitamin D.
Abstract
Objective
Evaluation of vitamin D supplementation on ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency.
Methods
The study is a before-and-after intervention study that was performed on women with diminished ovarian reserve referred to Shahid Mofteh Clinic in Yasuj, Iran. Eligible women were prescribed vitamin D tablets at a dose of 50,000 units weekly for up to 3 months. Serum levels of vitamin D and AMH were evaluated at the end of 3 months. Significance level was also considered P ≤ 0.05.
Results
Our results have been showed there was a statistically significant difference in vitamin D levels of participants before [12.1(6.5)] and after [26(9.15)] the intervention (P < 0.001). Moreover, there was a statistically significant difference in serum AMH levels of participants before [0.50(0.44)] and after [0.79(0.15)] the intervention (P=0.02 ).
Conclusion
In conclusion, the results of the current study support a possible favorable effect of vitamin D on increase AMH expression by acting on the AMH gene promoter. Therefore, it is possible that vitamin D increases AMH levels without changing the antral follicle count/ovarian reserve.
Topics
Keywords
Ovarian reserve, Vitamin D
