Glueck, C. J., Morrison, J. A., Wang, P., & Woo, J. G. (2013). Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later. Metabolism: clinical and experimental, 62(11), 1597-606. https://doi.org/10.1016/j.metabol.2013.07.005
Glueck CJ, Morrison JA, Wang P, Woo JG. Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later. Metabolism: clinical and experimental. 2013;62(11):1597-606. doi:10.1016/j.metabol.2013.07.005
Glueck, Charles J., et al. "Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later." Metabolism: clinical and experimental, vol. 62, no. 11, 2013, pp. 1597-606.
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Cincinnati Children's Hospital Medical Center01hcyya48
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Abstract
Objective
We determined whether simple, clinical information on late and early menarche could help identify adult women with metabolic syndrome (MetS) and oligomenorrhea.
Materials and Methods
We carried out a 26-year prospective follow-up of 272 suburban schoolgirls from ages 5-22 to 30-46.
Results
Early menarche (≤10 years, 5.2% of girls) and late menarche (≥16 years, 6.7% of girls) were both associated with oligomenorrhea (≥42 days) in adulthood, 29% and 11%, vs. 5% for normal menarche (11-15 years), p=.004. Early menarche was characterized by high childhood BMI (LS mean±SE: 21.2 ±1.0 kg/m2) and by high childhood and adult MetS (15%, 36%). Girls with late menarche had the lowest childhood BMI (18.1±1.0), no childhood MetS, and the highest adult MetS (47%). Increasing age at menarche was associated with uniformly decreasing childhood BMI and MetS, but with a U-shaped pattern of BMI (p = .05), MetS (p=.008), and oligomenorrhea (p=.02) in adulthood. Change to MetS from median ages 13 to 38 was associated with early-late menarche (OR=3.11, 95% CI 1.37-7.07, p=.007). MetS in adulthood was associated with childhood MetS (OR=8.03, 95% CI 2.57-25.08, p=.0003) and with early-late menarche (OR =3.43, 95% CI 1.44-8.15, p=.005).
Conclusions
Menarche age had a curvilinear ('U' shaped) relationship with MetS and oligomenorrhea in adulthood. Late menarche and early menarche are risk factors for adult oligomenorrhea, MetS, and cardiometabolic abnormalities. Girls with early (≤ age 10) and with late menarche (≥ 16) represent a group at high risk for adult cardiometabolic abnormalities and oligomenorrhea that is easily identifiable by physicians.
Menstrual Cycle › Cycle Across the Lifespan › Cycle and General Health · Longevity and Reproductive Aging › Lifespan Health › Cycle as a Lifespan Health Marker
Charles J Glueck, John A Morrison, Ping Wang, Jessica G Woo
Charlie Glueck, Chuck Glueck, C Glueck, Jack Morrison, J Morrison, P Wang, Jess Woo, J Woo
PMID 23953892 23953892 DOI 10.1016/j.metabol.2013.07.005 10.1016/j.metabol.2013.07.005 Glueck et al. 2013, Glueck 2013
Keywords
95% CI, 95% confidence intervals, BMI, Body mass index, Cardiometabolic abnormalities, DBP, Early menarche, HDLC, LDLC, LRC, Late menarche, Lipid Research Clinics, MetS, Metabolic syndrome, OR, Oligomenorrhea, PFS, Princeton Follow-up Study, SBP, TG, diastolic blood pressure, high density lipoprotein cholesterol, low-density lipoprotein cholesterol, odds ratio, systolic blood pressure, triglyceride
