Efficacy of L-Arginine, Myoinositol, and Chromium with Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome: A Randomized Comparative Study

Nehal G Abd El-Aziz; Hasnaa Osama; Sara Abdallah Mohamed Salem; Hoda M Rabea

doi:10.1080/07435800.2026.2713536

Efficacy of L-Arginine, Myoinositol, and Chromium with Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome: A Randomized Comparative Study

Abd El-Aziz NG, Osama H, Salem SAM, Rabea HM

Published August 10, 2026 Endocrine research, 1-12

DOI 10.1080/07435800.2026.2713536 PMID 42573014

Abstract

Background

PCOS is a hormonal disorder with no medication, hence treatment is symptomatic. Letrozole plus chromium, L-arginine, or myoinositol was tested in PCOS-infertile women.

Methods

This prospective trial randomly assigned 240 PCOS patients (n = 60) to one of four groups: letrozole + chromium, L-arginine, myoinositol, or the control. Insulin resistance, testosterone, HOMA-IR, hirsutism, DHEA, and ovulatory function were examined before and after treatment.

Results

At each follow-up, all groups showed substantially different ovulation rates (p = 0.026, 0.039, and 0.008 at 1, 2, and 3 months, respectively). Weight, HOMA-IR, and hirsutism were decreased with chromium and myoinositol (p = 0.001). Chromium, myoinositol, and L-arginine significantly reduced testosterone. Myoinositol had the highest pregnancy rates at one and two months (36.7% and 41.9%, respectively).

Conclusion

letrozole combined with chromium or myoinositol improves PCOS ovulation, HOMA-IR, and hirsutism.

Nehal G Abd El-Aziz, Hasnaa Osama, Sara Abdallah Mohamed Salem, Hoda M Rabea

N El-Aziz, H Osama, S Salem, H Rabea

PMID 42573014 42573014 DOI 10.1080/07435800.2026.2713536 10.1080/07435800.2026.2713536 Abd El-Aziz et al. 2026, Abd El-Aziz 2026

Keywords

Chromium, DHEA, HOMA-IR, L-arginine, PCOS, letrozole, myoinositol, ovulation induction

Efficacy of L-Arginine, Myoinositol, and Chromium with Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome: A Randomized Comparative Study

Abstract

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