Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

Marléne Isaksson; Annarita Antelmi; Jakob Dahlin; Joanna Stenton; Cecilia Svedman; Erik Zimerson; Bo Glas; Lina Hagvall; Maria Lagrelius; Anna Löwnertz; Laura Malinauskiene; Mihaly Matura; Magnus Bruze

doi:10.1111/cod.14223

Lifestyle and Environment · Environmental Exposures

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

Isaksson M, Antelmi A, Dahlin J, Stenton J, Svedman C, Zimerson E, Glas B, Hagvall L, Lagrelius M, Löwnertz A, Malinauskiene L, Matura M, Bruze M

Published January 2023 Contact Dermatitis

DOI 10.1111/cod.14223 PMC PMC10091765

Abstract

Background

The textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD.

Objectives

To study if DO 3 can be excluded from TDM 6.6%.

Methods

Patch tests were performed on 1481 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet.

Results

Contact allergy to TDM 6.6% was 3.6% and to TDM 7.0% was 3.0%. All 26 DO 3-positive patients were positive to PPD. The 44 patients positive to TDM 7.0% plus the 13 positive to PPD and TDM 6.6% but negative to TDM 7.0% were 57, outnumbering the 53 positive to TDM 6.6%.

Conclusion

TDM 7.0% can replace TDM 6.6% in the Swedish baseline series, since TDM 7.0% together with PPD 1.0% will detect patients with textile dye allergy.

Topics

Lifestyle and Environment Environmental Exposures Textiles and Dyes

Lifestyle and Environment › Environmental Exposures › Textiles and Dyes

Marléne Isaksson, Annarita Antelmi, Jakob Dahlin, Joanna Stenton, Cecilia Svedman, Erik Zimerson, Bo Glas, Lina Hagvall, Maria Lagrelius, Anna Löwnertz, Laura Malinauskiene, Mihaly Matura, Magnus Bruze

M Isaksson, A Antelmi, J Dahlin, J Stenton, C Svedman, E Zimerson, B Glas, L Hagvall, M Lagrelius, A Löwnertz, L Malinauskiene, M Matura, M Bruze

DOI 10.1111/cod.14223 10.1111/cod.14223 Isaksson et al. 2023, Isaksson 2023

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

Abstract

Topics

By this author

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