Fertility and Sterility, 114(3), e206, 2020
Abstract not indexed. Read at publisher
Topics
infertility endometriosis risk factor association, endometriosis risk investigation infertility causal relationship, Schliep Peterson endometriosis infertility epidemiology, endometriosis etiology reproductive history risk factors, infertility as risk factor for endometriosis diagnosis, endometriosis prevalence infertile women population study, genetic epidemiology endometriosis infertility link, endometriosis pathogenesis reproductive dysfunction, family history endometriosis infertility risk assessment
DOI 10.1016/j.fertnstert.2020.08.585 10.1016/j.fertnstert.2020.08.585
Cite this article
Kiser, A. C., Henrie, A., Schliep, K. C., Peterson, C. M., Peterson, K., & Eilbeck, K. (2020). Investigating the role of infertility in endometriosis risk. Fertility and Sterility, 114(3), e206. https://doi.org/10.1016/j.fertnstert.2020.08.585
Kiser AC, Henrie A, Schliep KC, Peterson CM, Peterson K, Eilbeck K. Investigating the role of infertility in endometriosis risk. Fertility and Sterility. 2020;114(3):e206. doi:10.1016/j.fertnstert.2020.08.585
Kiser, A. C., et al. "Investigating the role of infertility in endometriosis risk." Fertility and Sterility, vol. 114, no. 3, 2020, pp. e206.
Related articles
EndometriosisEnvironmental ExposuresRisk FactorsMatched Cohort
Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study
Buck Louis GM et al., 2013·Fertil Steril
To assess in utero exposures and the odds of an endometriosis diagnosis. Matched cohort design. Fourteen participating clinical centers in geographically defined areas in Utah and California. PATIENT(S): Operative cohort comprised 473 women undergoing laparoscopy/laparotomy, and an ageand residence-matched population cohort comprising 127 women undergoing pelvic magnetic resonance imaging (MRI), 2007-2009. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Women completed standardized interviews mothers' lifestyle during the index pregnancy, and the index woman's gestation and birth size. Endometriosis was defined as visually confirmed disease in the operative cohort, and MRI visualized disease in the population cohort. The odds of an endometriosis diagnosis and corresponding 95% confidence intervals (CI) were estimated for each exposure by cohort using logistic regression and adjusting for current smoking, age at menarche, body mass index, and study site. RESULT(S): Endometriosis was diagnosed in 41% and 11% of women in the operative and population cohorts, respectively. In the primary analysis, adjust odds ratios (AORs) were elevated for maternal vitamin usage (1.27; 95% CI, 0.85-1.91), maternal cigarette smoking (1.16; 95% CI = 0.61-2.24), and low birth weight (1.1; 95% CI, 0.92-1.32). Reduced odds were observed for maternal usage of caffeine (0.99; 95% CI, 0.64-1.54), alcohol (0.82; 95% CI, 0.35-1.94), paternal cigarette smoking (0.72; 95% CI, 0.43-1.19), and preterm delivery (0.98; 95% CI, 0.47-2.03). Sensitivity analyses mostly upheld the primary results except for a decreased AOR for preterm birth (0.41; 95% CI, 0.18-0.94) when restricting to visualized and histologically confirmed endometriosis in the operative cohort. CONCLUSION(S): In utero exposures were not statistically significantly associated with the odds of an endometriosis diagnosis in either cohort.
Research
Diagnosis and treatment of luteal phase deficiency: a Committee Opinion
Practice Committee of the American Society for Reproductive Medicine and Practice Committee of the Society for Reproductive Endocrinology and Infertility, 2026·Fertility and sterility
Luteal phase deficiency (LPD) is a clinical diagnosis associated with abnormal luteal phase length of ≤10 days. Potential etiologies of LPD include inadequate progesterone duration, inadequate progesterone levels, or endometrial progesterone resistance. Luteal phase deficiency has been described in association with medical conditions, but also in fertile, normally menstruating women. Although progesterone is important for the process of implantation and early embryonic development, LPD has not been proven to be an independent entity causing infertility or recurrent pregnancy loss. Controversy exists regarding the multiple proposed measures for diagnosing LPD, and assuming it can be diagnosed accurately, whether treatment improves outcomes. This document replaces the document of the same name, last published in 2021 (Fertil Steril 2021;115(6):1416-23).
Research
Recurrent pregnancy loss: a committee opinion
Practice Committee of the American Society for Reproductive Medicine, 2026·Fertility and Sterility
Current strategies for the assessment and treatment of recurrent pregnancy loss are discussed. This replaces the previous document, titled, "Evaluation and treatment a committee opinion," last published in 2012.
Research
Optimization of conception with intercourse for women with infertility
Boedeker D et al., 2026·Fertility and sterility
This narrative review examines the evidence for medical optimization of inflammatory conditions, vitamin deficiencies, endocrine disorders, immune dysregulation, oligo-ovulation, and luteal phase factors to improve fertility outcomes in women attempting to conceive through natural or timed intercourse. Overall, there is a paucity of data with respect to these categories among patients pursuing timed intercourse, precluding our ability to draw strong recommendations. However, there is strong evidence supporting treatment of endocrine disorders, specifically overt thyroid dysfunction and hyperprolactinemia, as well as oligo-ovulation. Conversely, treatment of subclinical hypothyroidism is not recommended. The current data are insufficient to support empiric use of antiinflammatory medications, corticosteroids, thyroid hormones, or vitamins or supplements to improve chances of pregnancy in a general infertility population.