Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis

Amiram Fishman; Dilaver Demirel; Rodolfo Laucirica; Ibrahim Ramzy; Tomas Klima; Judy Lyzak; Alan L. Kaplan

doi:10.1016/s0301-2115(96)02563-8

General Gynecology · Gynecologic Oncology

Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis

Fishman A, Demirel D, Laucirica R, Ramzy I, Klima T, Lyzak J, Kaplan AL

Published December 1996 European Journal of Obstetrics, Gynecology, and Reproductive Biology, 70(1), 69-74

DOI 10.1016/s0301-2115(96)02563-8 PMID 9031923

Abstract

Background

Malignant transformation to endometriosis is a well documented phenomenon that occurs most commonly in the ovaries with cancer arising in extra-ovarian endometriosis being a rare event.

Methods

A retrospective clinical-pathological evaluation of eleven cases with malignant tumors arising in endometriosis was performed to evaluate the prognostic impact of various factors. Nuclear DNA content (ploidy) was assessed through flow cytometric study.

Results

Ovarian origin was identified in eight cases and three were associated with extra-ovarian endometriosis. Histologic type was endometrioid carcinoma in ten patients. The eleventh case had high grade endometrial stromal sarcoma. All tumors were diploid with no relation to stage, grade, or clinical outcome. The S-phase fraction (SPF) was analyzed in nine patients and no correlation could be demonstrated with any histologic parameters or clinical outcome.

Conclusions

The DNA content seems to have no association with the classical prognostic parameters in these cases.

Topics

General Gynecology Gynecologic Oncology Ovarian Cancer

General Gynecology › Gynecologic Oncology › Ovarian Cancer

Amiram Fishman, Dilaver Demirel, Rodolfo Laucirica, Ibrahim Ramzy, Tomas Klima, Judy Lyzak, Alan L. Kaplan

A Fishman, D Demirel, R Laucirica, I Ramzy, T Klima, J Lyzak, A Kaplan

PMID 9031923 9031923 DOI 10.1016/s0301-2115(96)02563-8 10.1016/s0301-2115(96)02563-8 Fishman et al. 1996, Fishman 1996

Keywords

Adult, Aged, Carcinoma, Endometrioid/etiology/pathology, Cell Transformation, Neoplastic, DNA/analysis, Endometrial Neoplasms/etiology/pathology, Endometriosis/complications/pathology/surgery, Female, Flow Cytometry, Genital Neoplasms, Female/etiology/pathology, Humans, Middle Aged, Ovarian Neoplasms/etiology/pathology, Pelvic Neoplasms/etiology/pathology/therapy, Ploidies, Prognosis, Retrospective Studies, Sarcoma/etiology/pathology, Vaginal Neoplasms/etiology/pathology/surgery, DNA

Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis

Abstract

Topics

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Keywords