Naltrexone: A History and Future Directions

Srivastava AB, Gold MS

Published February 13, 2019 Cerebrum : the Dana Forum on Brain Science, 2018, cer-13-18
PMID 30746025

Abstract

Trying to kick drug addiction without medicines is said to be like relying on willpower to overcome diabetes or asthma. Enter naltrexone, which has been around since 1984 and reduces the cravings for drugs and alcohol by fine-tuning the brain's chemical reward system. Why has it recently increased in popularity? How does it compare to similar strategies? Has it made a difference? Our authors, who have long studied addiction and the brain, confront a drug and alcohol addiction problem that today kills more Americans each day than gun violence or car accidents.

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Mark S Gold, A Benjamin Srivastava
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PMID 30746025 30746025 Srivastava et al. 2019, Srivastava 2019