OBJECTIVE: To assess the use of magnetic resonance imaging (MRI) to determine the varying distribution of a vaginally placed gel over time and with different levels of patient activity.
DESIGN: Prosp...
Context: Identification of women with low bone mineral density (BMD) is an important strategy in reducing the incidence of osteoporotic fractures. However, screening all women is not recommended.
Obj...
Bone Health > Screening > Osteoporosis Risk Assessment ToolsBone Health > Diagnostics > Bone Densitometry DXAPerimenopause/Menopause > Bone Health > Fracture Risk Prediction
Ahokas A et al., 2001The Journal of Clinical Psychiatry
BACKGROUND: The postpartum period is a time when women are vulnerable to depressive disorders, which can be severe and have long-lasting adverse sequelae. In spite of multiple contacts with health car...
Several studies indicate that parity and lactation are associated with modest, short-term bone loss, but the long-term effect on osteoporotic fracture risk is uncertain. The authors therefore analyzed...
Bone Health > Fracture Risk > Parity and Lactation EffectsPostpartum > Breastfeeding > Long-term Bone Health OutcomesContraception/Comparison > Side Effects > Oral Contraceptives and Bone
Kurtzman JT et al., 2001Seminars in Reproductive Medicine
The role of human chorionic gonadatropin (hCG) in the maintenance of early pregnancy is well known. Recent data suggests that hCG may play a role in the maintenance of the later stages of pregnancy as...
Stanczyk FZ, 2001The Journal of Reproductive Medicine
Progestogens, which include the natural hormone, progesterone, and synthetic steroid derivatives, are used to treat a variety of reproductive disorders. Since synthetic progestogens are often associat...
Licht P et al., 2001Seminars in Reproductive Medicine
Recent evidence suggests that human chorionic gonadotropin (hCG), in addition to its well-known endocrine effects on the corpus luteum, may act as a growth and differentiation factor during pregnancy....
Reproductive Endocrinology > hCG > Embryo-Endometrial SignalingInfertility > Implantation > hCG Role in Endometrial ReceptivityReproductive Endocrinology > hCG > Growth and Differentiation Factor
Fanchin R et al., 2001Seminars in Reproductive Medicine
Human chorionic gonadotropin (hCG) is widely used as a surrogate to luteinizing hormone (LH) to trigger ovulation in controlled ovarian hyperstimulation (COH). Yet this molecule may exert direct effec...
Sauer MV, 2001The Journal of Reproductive Medicine
Progesterone, supplied in a variety of formulations, is commonly used in assisted reproduction. However, even the commonly accepted uses of progesterone in fertility care are believed to be largely em...
Infertility > Assisted Reproduction > Progesterone SupplementationReproductive Endocrinology > Progesterone > Clinical Use in FertilityInfertility > Treatment > Luteal Phase Support
OBJECTIVE: To determine the association between indomethacin tocolysis and neonatal intraventricular hemorrhage.
METHODS: Fifty-six preterm neonates with intraventricular hemorrhage were matched by g...
OBJECTIVE: To compare the psychopathology, personality features, and marital relationships of women undergoing in vitro fertilization (IVF) with those of control patients, and to compare IVF inductees...
General OB/GYN > Assisted Reproduction > Psychological Impact of IVFInfertility > Psychosocial Aspects > Marital RelationshipsGeneral OB/GYN > Mental Health > Anxiety in Reproductive Medicine
OBJECTIVE: To investigate whether uterine contractility at the time of embryo transfer (ET) can be reduced by early onset of luteal support with progesterone administered vaginally.
DESIGN: Prospecti...
Infertility > Assisted Reproduction > Embryo Transfer OptimizationReproductive Endocrinology > Progesterone > Uterine ContractilityInfertility > IVF > Luteal Phase Support
Fehring RJ et al., 2001Journal of Midwifery & Women's Health
The purpose of this study was to describe and assess certified nurse-midwives' (CNMs) knowledge and promotion of two modalities for child spacing, natural family-planning (NFP) and the lactational ame...
Body Literacy > Education > Healthcare Provider KnowledgeFertility Awareness > Clinical Practice > Provider Promotion of NFPPostpartum > Lactational Amenorrhea > Child Spacing Methods
OBJECTIVE: To analyse the relationship between endometriosis and epithelial ovarian cancer.
METHODS: We analyzed retrospectively the 20 cases associated with endometriosis in 371 cases of epithelial ...
Endometriosis > Complications > Malignant TransformationEndometriosis > Pathophysiology > Association with Ovarian CancerGeneral OB/GYN > Gynecologic Oncology > Endometriosis-Related Carcinoma
Rasmussen SA et al., 2001The Journal of Pediatrics
OBJECTIVE: To investigate the relationship between prematurity and birth defects.
STUDY DESIGN: In a population-based cohort study, infants with birth defects were ascertained through the Metropolita...
S I Barr et al., 2001Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
This 2-year prospective study examined associations among bone mineral acquisition and physical, maturational, and lifestyle variables during the pubertal transition in healthy girls. Forty-five girls...
Bone Health > Pediatric > Pubertal Bone Mineral AcquisitionMenstrual Cycle > Puberty > Growth and DevelopmentBone Health > Nutrition > Calcium Intake and Bone Density
OBJECTIVE: To compare the rates of ovulation and pregnancy after tamoxifen citrate (TMX) or clomiphene citrate (CC) among anovulatory women with infertility.
DESIGN: Prospective randomized trial.
SE...
BACKGROUND: This study was designed to examine basal and stress-induced levels of the neuroactive progesterone metabolite, allopregnanolone, in women with premenstrual dysphoric disorder (PMDD) and he...
Padberg S et al., 2001Thyroid : Official Journal of the American Thyroid Association
Studies in animal models of spontaneous Hashimoto's autoimmune thyroiditis (HT) show that prophylactic treatment with levothyroxine (LT4) can reduce incidence and degree of lymphocytic infiltration in...
Gücer F et al., 2001The Journal of Reproductive Medicine
OBJECTIVE: To evaluate maternal serum tumor necrosis factor-alpha (TNF alpha) levels in patients with preterm labor without clinical signs of chorioamnionitis and to compare these with levels in nonla...
Kalro BN et al., 2001Obstetrics and Gynecology Clinics of North America
Although central and peripheral factors have been implicated in the neuromodulation of GnRH in PCOS, there are no definitive or conclusive data to establish a primary causal role for any one factor. B...
OBJECTIVE: To compare subcutaneous (SC) and intramuscular (IM) hCG administration and their association with body mass index (BMI) in women undergoing IVF-ET using hMG and ICSI.
DESIGN: Prospective, ...
Severy L, 2001The Journal of International Medical Research
This paper considers the concept of consumer acceptance of medical products and its importance to successful healthcare provision. The critical dimensions ('domains') of acceptance for a product desig...
Fertility Awareness > Technology > Home Monitoring DevicesFertility Awareness > Acceptability > User ExperienceResearch Methodology > Psychometric Assessment
Zuppa AA et al., 2001European Journal of Obstetrics, Gynecology, and Reproductive Biology
OBJECTIVES: Over the last 10 years, diffusion of assisted reproduction techniques (ovarian stimulation, IVF, GIFT) has led to an increased incidence of multiple pregnancies and consequently, of the re...
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. New treatment approaches resulting from a refined understanding of the pathophysiology are evolving. Th...
S B Roberts et al., 2001J Gerontol A Biol Sci Med Sci
Caloric restriction (CR) reduces the rate of aging and increases life span in all small animal species studied to date, but the effects of CR in humans remain uncertain. This review summarizes current...
Josefsson A et al., 2001Acta Obstetricia Et Gynecologica Scandinavica
BACKGROUND: Postnatal depression refers to a non-psychotic depressive episode that begins in or extends into the postpartum period. The aims of this study were to examine the prevalence of depressive ...
A Tenenhouse et al., 2001Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
The Canadian Multicentre Osteoporosis Study (CaMos) is a prospective cohort study which will measure the incidence and prevalence of osteoporosis and fractures, and the effect of putative risk factors...
Bone Health > Epidemiology > Osteoporosis PrevalenceBone Health > Diagnostics > DXA Reference StandardsPerimenopause/Menopause > Bone Health > Bone Mineral Density
OBJECTIVE: To use aromatase inhibition for induction of ovulation in women in whom clomiphene citrate (CC) treatment was unsuccessful.
DESIGN: Prospective trial in infertility patients treated with C...
Vandermolen DT et al., 2001Fertility and Sterility
OBJECTIVE: To determine whether metformin treatment increases the ovulation and pregnancy rates in response to clomiphene citrate (CC) in women who are resistant to CC alone.
DESIGN: Randomized, doub...
Dmowski WP et al., 2001The Journal of the American Association of Gynecologic Laparoscopists
Small bowel involvement by endometriosis occurs in about 0.5% of patients, but nodular endometriosis involving the entire wall of the terminal ileum is extremely rare. Endometriotic nodules protruding...
The objective of this effort was to assess the use and efficacy of the Lactational Amenorrhea Method (LAM) with reduced numbers of client-provider contacts. A co-sponsored multicenter study of LAM was...
It is likely that heritable genetic factors contribute to the development of endometriosis, which is a putative precursor of the endometrioid and clear cell histological subtypes of ovarian cancer. Th...
Over the past 20 years, it has been clearly documented that the polycystic ovary syndrome (PCOS) has major metabolic sequelae related to insulin resistance and that insulin resistance plays an importa...
OBJECTIVES: To compare the efficacy and tolerability of agnus castus fruit (Vitex agnus castus L extract Ze 440) with placebo for women with the premenstrual syndrome.
DESIGN: Randomised, double blin...
OBJECTIVE: To investigate the contributions of ovulation-inducing drugs and assisted reproductive technologies to multiple birth.
METHODS: This historic prospective study was conducted in a cohort of...
Infertility > ART Outcomes > Multiple PregnanciesInfertility > ART Risks > Maternal and Neonatal MorbidityPregnancy > Complications > Multiple Gestation
OBJECTIVE: To determine whether metformin would safely reduce the rate of first-trimester spontaneous abortion without teratogenicity in 19 women with the polycystic ovary syndrome (PCOS).
DESIGN: Pr...
Kahsar-Miller MD et al., 2001Fertility and Sterility
OBJECTIVE: To determine the rate of clinically evident polycystic ovary syndrome (PCOS) among first-degree female relatives within families with a proband affected by PCOS.
DESIGN: Clinical and bioch...
OBJECTIVE: To assess the reliability of the most widely used clinical methods for predicting or confirming ovulation.
METHODS: We monitored spontaneous cycles in 101 infertile women using basal body ...
OBJECTIVE: To relate serum allopregnanolone and progesterone levels postpartum to maternity "blues."
METHODS: Forty primiparous, healthy, married women (24-39 years of age; at least 13 years of educa...
Kashyap S et al., 2001The Journal of Reproductive Medicine
OBJECTIVE: To compare the incidence of pregnancy-induced hypertension in patients with and without polycystic ovary disease (PCOD).
STUDY DESIGN: We conducted a retrospective, case-control analysis o...
Macas E et al., 2001Human Reproduction (Oxford, England)
The potential risk of transmitting chromosomally abnormal spermatozoa from infertile males into oocytes through intracytoplasmic sperm injection (ICSI) has prompted us to investigate the male pronucle...
Mather KJ et al., 2001The Journal of Clinical Endocrinology and Metabolism
Regularly menstruating women are relatively protected from cardiovascular disease. Epidemiological and endothelial function studies attribute this protection to estradiol (E(2)), but both progesterone...
Kobayashi K et al., 2001Annals of the New York Academy of Sciences
The Federal Food, Drug, and Cosmetic Act and related regulations (21 U.S.C. 301 et seq.) give FDA staff the legal authority and responsibility to review the safety and effectiveness of drugs and biolo...
Ethics/Philosophy > Regulatory Framework > FDA Drug ApprovalResearch Methodology > Regulatory Processes > Drug Development Oversight