Kashyap, S., & Claman, P. (2000). Polycystic ovary disease and the risk of pregnancy-induced hypertension. The Journal of Reproductive Medicine, 45(12), 991-994.
Kashyap S, Claman P. Polycystic ovary disease and the risk of pregnancy-induced hypertension. J Reprod Med. 2000;45(12):991-994.
Kashyap, S., and P. Claman. "Polycystic ovary disease and the risk of pregnancy-induced hypertension." The Journal of Reproductive Medicine, vol. 45, no. 12, 2000, pp. 991-994.
To compare the incidence of pregnancy-induced hypertension in patients with and without polycystic ovary disease (PCOD).
Study Design
We conducted a retrospective, case-control analysis of patients who achieved singleton pregnancies with human menopausal gonadotropin (hMG) therapy. Twenty-two PCOD patients were compared to 27 infertility patients without PCOD who were pregnant after hMG therapy. Non-PCOD patients received hMG for superovulation as part of superovulation/intrauterine insemination or in vitro fertilization/embryo transfer. PCOD patients were receiving hMG for simple ovulation induction. Pregnancy-induced hypertension was defined as late pregnancy blood pressure > 140/90 mm Hg on two readings six hours apart and return to normal blood pressure by four to six weeks postpartum.
Results
There were no differences between PCOD and non-PCOD patients with reference to age, body mass index, parity or other pregnancy-induced hypertension risk factors (i.e., chronic hypertension, diabetes or chronic renal disease). Pregnant PCOD patients had a much higher incidence of pregnancy-induced hypertension, 31.8% (7/22), versus non-PCOD patients, who only had a pregnancy-induced hypertension incidence of 3.7% (1/27) (P = .016, OR = 12.1, 95% CI = 1.3-566.8).
Conclusion
PCOD patients are at very high risk of pregnancy-induced hypertension when pregnant after ovulation induction.
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