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Polycystic ovary syndrome: a changing perspective

Franks S, 1989 Clinical Endocrinology

Few subjects have provoked such controversy in the field of reproductive endocrinology as polycystic ovary syndrome (PCOS). It is characterized by heterogeneous clinical and endocrine features and thi...

PCOS > Diagnosis > Evolving Diagnostic CriteriaPCOS > Pathophysiology > Endocrine Features and HeterogeneityReproductive Endocrinology > Hyperandrogenism > Polycystic Ovary Syndrome

Perspectives of physicians in Sri Lanka on periodic abstinence

Perera HW et al., 1989 The Ceylon Medical Journal

Since physicians strongly influence both national family planning policy and individuals' contraceptive choice, a survey was conducted to learn about the perspectives of Sri Lankan physicians (n-100) ...

Fertility Awareness > Provider Education > Physician AttitudesFertility Awareness > Methods > Periodic AbstinenceResearch Methodology > Survey Studies > Cross-Sectional

Prevention of postsurgical adhesions by INTERCEED(TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. INTERCEED(TC7) Adhesion Barrier Study Group

Adhesion Barrier Study Group, 1989 Fertility and Sterility

INTERCEED(TC7) (Johnson & Johnson Patient Care Inc., New Brunswick, NJ) is an absorbable fabric specially designed to reduce postsurgical adhesions. The authors report on a prospective, randomized, mu...

Surgery > Adhesion Prevention > Barrier MethodsInfertility > Surgical Treatment > Pelvic AdhesiolysisResearch Methodology > Randomized Controlled Trials > Multicenter Studies

Diagnosis and management of out-of-phase endometrial biopsies among patients receiving clomiphene citrate for ovulation induction

Keenan JA et al., 1989 Fertility and Sterility

Eighty-seven patients who underwent a late secretory phase endometrial biopsy while taking clomiphene citrate (CC) for ovulation induction were studied. Of the endometrial biopsies, 21 (24%) showed an...

Infertility > Ovulation Induction > Clomiphene CitrateDiagnostics > Endometrial Biopsy > Luteal Phase AssessmentReproductive Endocrinology > Luteal Phase Defect > Diagnosis and Treatment

Gamete membrane fusion in hamster spermatozoa with reacted equatorial segment

Vigil P, 1989 Gamete research

Mammalian spermatozoa must undergo many changes to be able to fertilize the oocyte. One of these changes, the acrosome reaction, has been established as a requisite for gamete membrane fusion to occur...

Reproductive Endocrinology > Gamete Biology > Sperm Acrosome ReactionReproductive Endocrinology > Fertilization > Gamete Membrane FusionResearch Methodology > Laboratory Studies > Ultrastructural Analysis

Potential use of C-reactive protein determinations in obstetrics and gynecology

Chaisilwattana P et al., 1989 Obstetrical & Gynecological Survey

C-reactive protein (CRP) is an acute-phase protein synthesized by the liver during the course of a large number of diseases. During gestation and parturition, progressively increasing numbers of gravi...

Pregnancy > Complications > Preterm DeliveryPregnancy > Infections > Asymptomatic BacteriuriaResearch Methodology > Meta-Analysis > Obstetric Outcomes

Tamoxifen treatment in women with failure of clomiphene citrate therapy

Borenstein R et al., 1989 The Australian & New Zealand Journal of Obstetrics & Gynaecology

Fourteen pregnancies were achieved with tamoxifen therapy in 12 women who failed to conceive with clomiphene citrate. There were no side-effects and fewer treatment cycles were required than with clom...

Infertility > Ovulation Induction > TamoxifenInfertility > Ovulation Induction > Clomiphene Citrate AlternativesReproductive Endocrinology > Selective Estrogen Receptor Modulators > Fertility Applications

How precise is histologic dating of endometrium using the standard dating criteria?

Li TC et al., 1989 Fertility and Sterility

Sixty-three endometrial biopsies were dated histologically by using the standard criteria on two separate occasions by the same observer. Overall, it was found that exact agreement occurred in 15 (24%...

Diagnostics > Endometrial Biopsy > Dating PrecisionMenstrual Cycle > Luteal Phase > Endometrial AssessmentResearch Methodology > Reproducibility > Observer Variability

Decreased follicular phase gonadotropin secretion is associated with impaired estradiol and progesterone secretion during the follicular and luteal phases in normally menstruating women

Schweiger U et al., 1989 The Journal of Clinical Endocrinology and Metabolism

We tested the hypothesis that disturbed follicular development and disturbed luteal progesterone (P4) secretion are associated with reduced gonadotropin secretion in the early follicular phase by meas...

General OB/GYN > Infection > Inflammatory MarkersDiagnostics > Biomarkers > C-Reactive ProteinPregnancy > Complications > Infectious Morbidity

Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight

Romero R et al., 1989 Obstetrics and Gynecology

The relationship between asymptomatic bacteriuria and prematurity/low birth weight (LBW) is still a controversial issue, despite many studies. Meta-analysis, a research tool designed to analyze and co...

Reproductive Endocrinology > Menstrual Cycle Physiology > Ovarian-Pituitary AxisMenstrual Cycle > Follicular Development > Gonadotropin RegulationReproductive Endocrinology > Endometrial Physiology > Maturation and Shedding

Follicle size by ultrasound versus cervical mucus quality: normal and abnormal patterns in spontaneous cycles

Daly DC et al., 1989 Fertility and Sterility

Ultrasound (US) has been demonstrated to be the method of choice for diagnosing luteinized unruptured follicle syndrome and to be a valuable adjuvant in the assessment of luteal phase defect. In this ...

Menstrual Cycle > Ovulation Monitoring > Ultrasound Follicle TrackingDiagnostics > Cervical Mucus Assessment > Insler ScoreInfertility > Diagnostic Evaluation > Postcoital Testing

Twenty-four-hour progesterone and luteinizing hormone profiles in the midluteal phase of the infertile patient: correlation with other indicators of luteal phase insufficiency

Olive DL et al., 1989 Fertility and Sterility

The authors have further analyzed women diagnosed as having luteal phase insufficiency in hope of determining the value of specific screening tests as well as determining the degree of heterogeneity o...

Infertility > Luteal Phase Defect > Diagnostic EvaluationReproductive Endocrinology > Progesterone > Luteal Phase ProfilesDiagnostics > Endometrial Biopsy > Luteal Phase Dating

The incidence of luteal phase defect in normal, fertile women, determined by serial endometrial biopsies

Davis OK et al., 1989 Fertility and Sterility

Five regularly menstruating women of proven fertility, with normal prolactin and thyroid function studies, underwent a total of 39 endometrial biopsies (EMBs). The slides were dated in blinded fashion...

Infertility > Luteal Phase Defect > Diagnostic CriteriaDiagnostics > Endometrial Biopsy > Accuracy and ReproducibilityResearch Methodology > Diagnostic Test Evaluation > Reference Standards

Origin of luteinizing hormone-releasing hormone neurons

Schwanzel-Fukuda M et al., 1989 Nature

Neurons expressing luteinizing hormone-releasing hormone (LHRH), found in the septal-preoptic nuclei and hypothalamus, control the release of gonadotropic hormones from the anterior pituitary gland an...

Reproductive Endocrinology > GnRH Physiology > Neuron Development and MigrationReproductive Endocrinology > Hypothalamic-Pituitary Axis > EmbryologyInfertility > Hypogonadotropic Hypogonadism > Kallmann Syndrome

C-reactive protein in preterm labour: association with outcome of tocolysis and placental histology

Cammu H et al., 1989 British Journal of Obstetrics and Gynaecology

Tocolytics were administered in 66 consecutive women in uncomplicated preterm labour with intact fetal membranes (53 singleton and 13 twin pregnancies). C-reactive protein (CRP), a marker of infection...

Pregnancy > Preterm Labor > Infection BiomarkersPregnancy > Preterm Labor > Tocolysis OutcomesDiagnostics > Inflammatory Markers > C-Reactive Protein in Pregnancy

Oral contraception, smoking and inflammatory bowel disease--findings in the Royal College of General Practitioners Oral Contraception Study

Logan RF et al., 1989 International Journal of Epidemiology

Data from the Royal College of General Practitioners Oral Contraception Study have been examined to determine whether oral contraceptive use was associated with the development of Crohn's disease or u...

Contraception/Comparison > Oral Contraceptives > Gastrointestinal Side EffectsContraception/Comparison > Oral Contraceptives > Inflammatory Bowel Disease RiskResearch Methodology > Epidemiological Studies > Prospective Cohort

The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume

Eden JA et al., 1989 Obstetrics and Gynecology

Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, through...

Infertility > Ovulation Induction > Clomiphene Citrate Side EffectsReproductive Endocrinology > Endometrial Development > Anti-Estrogen EffectsDiagnostics > Ultrasound > Endometrial Thickness Monitoring

Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in athletic women

Loucks AB et al., 1989 The Journal of Clinical Endocrinology and Metabolism

The functional integrity of the hypothalamic-pituitary-ovarian and hypothalamic-pituitary-adrenal axes was assessed by determining pulsatile LH, ACTH, and cortisol secretion during the early follicula...

Menstrual Cycle > Menstrual Dysfunction > Exercise-Associated AmenorrheaReproductive Endocrinology > Hypothalamic-Pituitary Axis > LH PulsatilityReproductive Endocrinology > HPA Axis > Cortisol and Reproductive Function

Self-esteem, spiritual well-being, and intimacy: a comparison among couples using NFP and oral contraceptives

Fehring RJ et al., 1989 International review (Steubenville, Ohio)

The purpose of this study was to compare the intimacy, spiritual well being (SWB), and self-esteem of couples using natural family planning (NFP) with those couples using oral contraceptives (OCs). 22...

Fertility Awareness > Psychosocial Outcomes > Couple RelationshipsContraception/Comparison > NFP vs Hormonal Contraception > Psychosocial EffectsBody Literacy > Fertility Awareness Methods > Creighton Model

Oral clomiphene citrate and vaginal progesterone suppositories in the treatment of luteal phase dysfunction: a comparative study

Murray DL et al., 1989 Fertility and Sterility

Oral clomiphene citrate (CC) and vaginal progesterone suppositories (PS) are common treatment modalities in luteal phase dysfunction (LPD). Little is known regarding the relative efficacy of these age...

Infertility > Luteal Phase Defect > Treatment ComparisonInfertility > Medical Treatment > Clomiphene CitrateInfertility > Medical Treatment > Progesterone Supplementation

Correlation of endometrial maturation with four methods of estimating day of ovulation

Shoupe D et al., 1989 Obstetrics and Gynecology

Dating of maturity of the endometrium by histologic examination was correlated with four methods of ovulation detection in 13 cycling parous women. Histologic dating was assessed independently by two ...

Menstrual Cycle > Luteal Phase > Endometrial DatingDiagnostics > Ovulation Detection > Ultrasound vs Hormonal MethodsReproductive Endocrinology > Ovarian Hormones > Progesterone and Estradiol Secretion

Bone mineral density in women with endometriosis before and during ovarian suppression with gonadotropin-releasing hormone agonists or danazol

Halstead L et al., 1989 Fertility and sterility

Lumbar bone mineral density (BMD) was evaluated by dual photon absorptiometry (DPA) in 38 women with laparoscopically diagnosed and staged endometriosis. DPA was performed before and at the completion...

Endometriosis > Medical Treatment > GnRH Agonist TherapyBone Health > Drug Effects > Ovarian Suppression and Bone DensityEndometriosis > Medical Treatment > Danazol

Inability of sonography to detect imminent ovulation

Zandt-Stastny D et al., 1989 AJR. American Journal of Roentgenology

Sonographic visualization of the cumulus oophorus or of morphologic alterations in the wall of the dominant follicle have been reported to be reliable signs of imminent ovulation when conventional tra...

Diagnostics > Ovulation Detection > Ultrasound MonitoringReproductive Endocrinology > Follicular Development > Sonographic AssessmentInfertility > Monitoring > Follicular Tracking

Intense Exercise During the First Two Trimesters of Unapparent Pregnancy

Cohen GC et al., 1989 The Physician and Sportsmedicine

In brief: Two runners who were not aware they had conceived continued their intense running regimens during the first and second trimesters of pregnancy. Both women assumed that their amenorrhea was d...

Pregnancy > Maternal Health > Exercise During PregnancyMenstrual Cycle > Amenorrhea > Exercise-Associated AmenorrheaGeneral OB/GYN > Lifestyle Factors > Physical Activity and Reproduction

Efficacy of human menopausal gonadotropins as therapy for abnormal cervical mucus

Soto-Albors C et al., 1989 Fertility and Sterility

Traditional therapies for abnormal cervical mucus, other than timed intrauterine insemination, are noteworthy for being ineffectual. Patients (n = 27) with documented abnormal Insler scores in repetit...

Infertility > Cervical Factor > Gonadotropin TherapyInfertility > Medical Treatment > Human Menopausal GonadotropinsDiagnostics > Cervical Mucus > Insler Score Assessment

The validity of gestational age estimation by menstrual dating in term, preterm, and postterm gestations

Kramer MS et al., 1988 JAMA

Despite recognition that estimation of gestational age (GA) based on maternal recollection of the last normal menstrual period (LNMP) is fraught with error, it is not generally appreciated that the ma...

Pregnancy > Gestational Age > Menstrual Dating AccuracyDiagnostics > Prenatal Assessment > Ultrasound vs Menstrual DatingGeneral OB/GYN > Obstetric Management > Postterm Pregnancy Diagnosis

The effect of interobserver variation in dating endometrial histology on the diagnosis of luteal phase defects

Scott RT et al., 1988 Fertility and Sterility

Endometrial biopsy specimens (n = 62) were evaluated by five pathologists to assess the effect of interobserver variation on histologic dating of the endometrium. The potential effect of this variatio...

Infertility > Luteal Phase Defect > Endometrial Biopsy DiagnosisDiagnostics > Endometrial Assessment > Interobserver VariabilityResearch Methodology > Diagnostic Accuracy > Pathologist Agreement

The luteinized unruptured follicle and other ovulatory dysfunctions

Katz E, 1988 Fertility and Sterility

DlJ. ring the last stage of puberty, the hypothalamic-pituitary-ovarian axis acquires the ability to respond to high levels of estradiol; this results in a sharp increase in the pituitary output of lu...

Reproductive Endocrinology > Ovulatory Dysfunction > Luteinized Unruptured FollicleInfertility > Ovulatory Disorders > Anovulation MechanismsMenstrual Cycle > Ovulation > Follicle Rupture and Luteinization

Spontaneous abortions in women with endometriosis

Pittaway DE et al., 1988 Fertility and Sterility

Pregnancy outcomes were evaluated retrospectively in 350 women to investigate the relationship between endometriosis and spontaneous abortions. The frequency of spontaneous abortions in women with end...

Endometriosis > Pregnancy Outcomes > Spontaneous AbortionInfertility > Secondary Infertility > Miscarriage RiskPregnancy > Pregnancy Loss > Endometriosis-Related

Use of the subcutaneous terbutaline pump for long-term tocolysis

Lam F et al., 1988 Obstetrics and Gynecology

Nine patients in preterm labor requiring long-term tocolysis were managed with subcutaneous terbutaline administered via a portable infusion pump. All had failed oral tocolytic therapy and were theref...

Pregnancy > Preterm Labor > TocolysisPregnancy > Preterm Labor > Outpatient ManagementGeneral OB/GYN > Drug Therapy > Terbutaline Administration

Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites

Arafat ES et al., 1988 American Journal of Obstetrics and Gynecology

Progesterone and its metabolites were measured in serum extracts by radioimmunoassay and gas chromatography-mass spectrometry, respectively, after ingestion of micronized progesterone by eight postmen...

Reproductive Endocrinology > Progesterone > Oral Administration PharmacologyReproductive Endocrinology > Progesterone > Metabolites and Side EffectsPerimenopause/Menopause > Hormone Therapy > Progesterone Effects

The Billings Ovulation Method. An update

Billings JJ et al., 1988 Australian Family Physician

Women can accurately predict the day of ovulation by examining vaginal mucus using the Billings Ovulation Method (BOM). they then can choose to either have sexual intercourse if they wish to conceive ...

Fertility Awareness > Billings Ovulation Method > MethodologyFertility Awareness > Cervical Mucus Monitoring > Ovulation PredictionBody Literacy > Fertility Signs > Mucus Observation

Endometriosis. Obtaining relief via 'near-contact' laparoscopy

Petersen NF et al., 1988 AORN Journal

Since 1979, Dr Redwine has performed the near-contact laparoscopy for the removal of endometriosis on nearly 400 women. Data collected from Dr Redwine's follow-up studies indicate that 75% of his pati...

Endometriosis > Surgical Treatment > Laparoscopic ExcisionSurgery > Laparoscopy > Near-Contact TechniqueEndometriosis > Pain Management > Surgical Outcomes

Characteristics of ovulation method acceptors: a cross-cultural assessment

Klaus H et al., 1988 Studies in Family Planning

Five programs of instruction in the ovulation method (OM) in diverse geographic and cultural settings are described, and characteristics of approximately 200 consecutive OM acceptors in each program a...

Fertility Awareness > Ovulation Method > User DemographicsFertility Awareness > Program Evaluation > Cross-Cultural StudiesResearch Methodology > Cross-Cultural Studies > Family Planning

Clinical trial of naltrexone in premenstrual syndrome

Chuong CJ et al., 1988 Obstetrics and Gynecology

Twenty women with the diagnosis of premenstrual syndrome (PMS) participated in a double-blind, placebo-controlled, crossover study to evaluate the efficacy of naltrexone, an oral opiate antagonist. Th...

Menstrual Cycle > Premenstrual Syndrome > Pharmacological TreatmentMenstrual Cycle > Premenstrual Syndrome > Opioid SystemResearch Methodology > Clinical Trials > Crossover Design

Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA

Julkunen M et al., 1988 FEBS Letters

The low-molecular-mass insulin-like growth factor-binding protein (IGF-BP) and placental protein 12 (PP12) are identical proteins that are present in human serum, amniotic fluid, secretory endometrium...

Reproductive Endocrinology > Growth Factors > IGF Binding ProteinsReproductive Endocrinology > Endometrial Biochemistry > Protein ExpressionPregnancy > Implantation > Decidual Proteins

Medroxyprogesterone acetate therapy in early pregnancy has no apparent fetal effects

Yovich JL et al., 1988 Teratology

Medroxyprogesterone acetate (MPA; Provera) was given orally to 449 women from the 5th to 7th week of pregnancy until at least the 18th week. Data are recorded from two treatment groups (recurrent abor...

Pregnancy > Threatened Abortion > Progestagen TreatmentPregnancy > Drug Safety > First Trimester ExposureInfertility > Recurrent Pregnancy Loss > Progesterone Therapy

The diagnosis of luteal phase deficiency: a critical review

McNeely MJ et al., 1988 Fertility and Sterility

Luteal phase deficiency is an ovulatory dysfunction problem that is subtle but real. It may be the most common ovulatory problem in women. Luteal phase deficiency has been clearly demonstrated in the ...

Reproductive Endocrinology > Luteal Phase Deficiency > Diagnostic MethodsDiagnostics > Hormonal Assessment > Progesterone MeasurementDiagnostics > Endometrial Biopsy > Luteal Phase Evaluation

Hyperinsulinemia and stromal luteinization of the ovaries in postmenopausal women with endometrial cancer

Nagamani M et al., 1988 The Journal of Clinical Endocrinology and Metabolism

Ovarian secretion of testosterone and androstenedione is increased in postmenopausal women with endometrial cancer, and insulin stimulates ovarian stromal androgen synthesis in vitro. We undertook thi...

Reproductive Endocrinology > Hyperinsulinemia > Ovarian Androgen ProductionPerimenopause/Menopause > Postmenopausal Pathology > Endometrial CancerGeneral OB/GYN > Gynecologic Oncology > Endometrial Carcinoma

The gamete and embryo compatibility of various synthetic polymers

Hunter SK et al., 1988 Fertility and Sterility

Several popular and well-characterized polymeric materials were evaluated for their biocompatibility toward the cells unique to reproduction. To accomplish these studies, several in vitro tests were d...

Research Methodology > In Vitro Testing > Biomaterial CompatibilityInfertility > Laboratory Methods > Gamete Handling Materials

Physicians' views of periodic abstinence methods: a study in four countries

Snowden R et al., 1988 Studies in Family Planning

A study of the knowledge, perceptions, and behavioral intentions of physicians regarding periodic abstinence (PA) methods was undertaken in Mauritius, Peru, the Philippines, and Sri Lanka. Most respon...

Fertility Awareness > Provider Education > Physician Knowledge and AttitudesRRM Methods > Acceptance and Promotion > Healthcare Provider PerspectivesEthics/Philosophy > Medical Practice > Family Planning Counseling

Assessment of carboxymethylcellulose and 32% dextran 70 for prevention of adhesions in a rabbit uterine horn model

Diamond MP et al., 1988 International Journal of Fertility

The ability of solutions of carboxymethylcellulose (CMC) and 32% dextran 70 to reduce postoperative adhesion formation was examined using a rabbit uterine-horn scrape model. Utilization of 50 mL of 32...

Surgery > Adhesion Prevention > Barrier SolutionsSurgery > Animal Models > Rabbit Uterine Horn ModelResearch Methodology > Preclinical Studies > Adhesion Prevention

Quantitation of uterine activity preceding preterm, term, and postterm labor

Nageotte MP et al., 1988 American Journal of Obstetrics and Gynecology

To assess uterine activity before labor in patients delivering preterm, at term, and postterm, the maximum spontaneous contraction frequency per 10-minute window during the initial portion of antepart...

Pregnancy > Preterm Labor > Uterine Activity MonitoringPregnancy > Labor Onset > Contraction Pattern AnalysisDiagnostics > Antepartum Monitoring > Uterine Activity Assessment

Endometriosis with unilateral ureteral obstruction and hypertension. A case report

Davis OK et al., 1988 The Journal of Reproductive Medicine

A patient developed hypertension from unilateral hydronephrosis produced by endometriosis. Her blood pressure fell promptly after decompression of the involved kidney.

Endometriosis > Extrapelvic Disease > Urinary Tract InvolvementEndometriosis > Complications > Ureteral ObstructionGeneral OB/GYN > Case Reports > Endometriosis Complications