Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Fejzo MS; Sazonova OV; Sathirapongsasuti JF; Hallgrímsdóttir IB; Vacic V; MacGibbon KW; Schoenberg FP; Mancuso N; Slamon DJ; Mullin PM; 23andMe Research Team

doi:10.1038/s41467-018-03258-0

Genetics and Immunology · Reproductive Genetics

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM, 23andMe Research Team

Published March 21, 2018 Nature communications, 9(1), 1178

DOI 10.1038/s41467-018-03258-0 PMID 29563502 PMC PMC5862842

Abstract

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p < 5 × 10-8) in both association scans and are replicated in an independent cohort. The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires further study, this GWAS provides insights into the genetic risk factors contributing to the disease.

Topics

Genetics and Immunology Reproductive Genetics Single Gene Conditions

Genetics and Immunology › Reproductive Genetics › Single Gene Conditions

PMID 29563502 29563502 DOI 10.1038/s41467-018-03258-0 10.1038/s41467-018-03258-0 Fejzo et al. 2018, Fejzo 2018

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Abstract

Topics

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