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Therapeutics · Emerging Therapies

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

Poorhassan M, Gholaminejhad M, Ahmadi H, Mehboudi L, Chahar Kameh M, Pirani M, Hassanzadeh G

Journal of lasers in medical sciences, 2022
DOI 10.34172/jlms.2022.75 PMID 37041786 PMC PMC10082901

Abstract

About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca2+, nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT.

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Therapeutics › Emerging Therapies › Light Therapy · Male Fertility › Male Factor Treatment › Medical Management
Mahnaz Poorhassan, Morteza Gholaminejhad, Houssein Ahmadi, Leila Mehboudi, Mahdis Chahar Kameh, Maryam Pirani, Gholamreza Hassanzadeh
M Poorhassan, M Gholaminejhad, H Ahmadi, L Mehboudi, M Kameh, M Pirani, G Hassanzadeh
PMID 37041786 37041786 DOI 10.34172/jlms.2022.75 10.34172/jlms.2022.75 Poorhassan et al. 2022, Poorhassan 2022

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