Teratology, 15(1), 25-32, 1977
Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice
Author affiliations
- National Institute of Environmental Health Sciences ROR
Abstract
Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.
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Cite this article
Andrew, F. D., & Staples, R. E. (1977). Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice. *Teratology*, *15*(1), 25-32. https://doi.org/10.1002/tera.1420150104
Andrew FD, Staples RE. Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice. Teratology. 1977;15(1):25-32. doi:10.1002/tera.1420150104
Andrew, F. D., and Robert E. Staples. "Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice." *Teratology*, vol. 15, no. 1, 1977, pp. 25-32.
Keywords
Abnormalities, Drug-Induced, Animals, Body Weight/drug Effects, Cleft Palate/chemically Induced, Dose-Response Relationship, Drug, Female, Fetal Death, Gestational Age, Maternal-Fetal Exchange, Medroxyprogesterone/toxicity, Mice, Pregnancy, Rabbits, Rats, Medroxyprogesterone