Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Andrew FD; Staples RE

doi:10.1002/tera.1420150104

Pregnancy · Fetal Medicine

Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Andrew FD, Staples RE

Published February 1977 Teratology, 15(1), 25-32

DOI 10.1002/tera.1420150104 PMID 841480

Abstract

Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.

Topics

Pregnancy Fetal Medicine Congenital Anomalies

Pregnancy › Fetal Medicine › Congenital Anomalies

PMID 841480 841480 DOI 10.1002/tera.1420150104 10.1002/tera.1420150104 Andrew et al. 1977, Andrew 1977

Keywords

Abnormalities, Drug-Induced, Animals, Body Weight/drug Effects, Cleft Palate/chemically Induced, Dose-Response Relationship, Drug, Female, Fetal Death, Gestational Age, Maternal-Fetal Exchange, Medroxyprogesterone/toxicity, Mice, Pregnancy, Rabbits, Rats, Medroxyprogesterone

Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Abstract

Topics

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