Noyes, R. W., Hertig, A. T., & Rock, J. (2019). Reprint of: Dating the Endometrial Biopsy. Fertility and Sterility, 112(4 Suppl1), e93-e115. https://doi.org/10.1016/j.fertnstert.2019.08.079
Noyes RW, Hertig AT, Rock J. Reprint of: Dating the Endometrial Biopsy. Fertil Steril. 2019;112(4 Suppl1):e93-e115. doi:10.1016/j.fertnstert.2019.08.079
Noyes, R. W., et al. "Reprint of: Dating the Endometrial Biopsy." Fertility and Sterility, vol. 112, no. 4 Suppl1, 2019, pp. e93-e115.
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Endometrial biopsy can estimate cycle day from tissue changes
This is a 1950 lab paper, reprinted in 2019. The paper describes tissue changes that can help estimate what day of the cycle a woman is on. The authors tested the method on 300 biopsies from patients evaluated for infertility. They also checked 40 patients against ovulation timing from temperature charts.
Key Findings
Redating 300 biopsies using the most advanced tissue area, the predicted day of menstruation matched actual onset within 1 day for 179 patients (60 percent).
Among 40 patients with basal body temperature records, predicted ovulation timing matched within 1 day for 31 patients (78 percent).
An earlier accuracy check of 200 biopsies, before this refinement, matched actual menstruation within 1 day for 97 patients (48 percent).
In a subgroup of 25 patients with extra temperature-charted cycles, the secretory phase of the biopsied cycle was shorter than usual in about two-thirds of them.
Interpretation
This is a descriptive 1950 lab paper, reprinted with no changes in 2019. The authors set out tissue features that show how far along the cycle is. They checked how well these estimates matched real menstruation and ovulation. The paper is not a clinical trial and tested no treatment. The patients were already being checked for infertility at one hospital lab. The authors suspected some error came from differences between observers, so one person later reviewed the slides. The paper also suggests, without proving it, that biopsy itself may shorten the second half of the cycle. The study does not test whether dating changes how infertility is diagnosed or treated.
RRM Context
Restorative reproductive medicine times tests, like an endometrial biopsy, to a woman's own observed ovulation. The approach does not use an assumed calendar day. This paper checks its tissue dating against ovulation from temperature charts. The comparison uses the same idea: it matches tissue to a real ovulation marker.
Our editorial summary of this paper, not the article's abstract.
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