More than one million new patients suffer from breast cancer annually in the world. In developed countries, breast cancer is the most common malignancy diagnosed among women, and in developing regions, it often ranks second to cervical cancer. This study aimed to investigate the relationship between incidence of breast cancer and reproductive factors in North-West of Iran. This retrospective analytical control-case study was conducted with 235 breast cancer patients and 235 women in the control group. Data collection tools included a set of questions with interviews and patient medical records. Data were analyzed using statistical tests: t-test, Chi-square, Fisher, and Pearson correlation coefficient. Significantly increased risks were associated between breast cancer and older age at first pregnancy, age at menopause and history of contraceptive use. A trend for decreasing risk were observed with increasing parity. Findings of this study showed no association between breast cancer and age at menarche. The study results suggested that physiological and reproductive factors may play important roles in the development breast cancer among Iranian women.
reproductive factors breast cancer risk Iran case-control, oral contraceptive use breast cancer risk Middle East, parity age first pregnancy breast cancer protective factor, age at menopause breast cancer risk Iranian women, contraceptive history breast cancer incidence developing countries, reproductive risk factors breast cancer North-West Iran, breastfeeding parity decreased breast cancer risk, age menarche menopause breast cancer association Iranian population, hormonal contraception breast cancer risk retrospective case-control, physiological reproductive factors breast cancer development women
PMID 25684470 25684470 DOI 10.7314/apjcp.2015.16.2.451 10.7314/apjcp.2015.16.2.451
Cite this article
Veisy, A., Lotfinejad, S., salehi, K., & Zhian, F. (2015). Risk of breast cancer in relation to reproductive factors in North-West of Iran, 2013-2014. Asian Pacific journal of cancer prevention : APJCP, 16(2), 451-455. https://doi.org/10.7314/apjcp.2015.16.2.451
Veisy A, Lotfinejad S, salehi K, Zhian F. Risk of breast cancer in relation to reproductive factors in North-West of Iran, 2013-2014. Asian Pac J Cancer Prev. 2015;16(2):451-455. doi:10.7314/apjcp.2015.16.2.451
Veisy, Afsaneh, et al. "Risk of breast cancer in relation to reproductive factors in North-West of Iran, 2013-2014." Asian Pacific journal of cancer prevention : APJCP, vol. 16, no. 2, 2015, pp. 451-455.
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