Successful Pregnancy Following Platelet-Rich Plasma Intraovarian Injection and In Vitro Maturation of Oocytes in a 47-Year-Old Woman: A Case Report

Nikos Petrogiannis; Kalliopi Chatzovoulou; Maria Filippa; Savvas Petrogiannis; Katerina Chatzimeletiou

doi:10.7759/cureus.65281

Assisted Reproduction · Add-Ons and Adjuncts

Successful Pregnancy Following Platelet-Rich Plasma Intraovarian Injection and In Vitro Maturation of Oocytes in a 47-Year-Old Woman: A Case Report

Petrogiannis N, Chatzovoulou K, Filippa M, Petrogiannis S, Chatzimeletiou K

Published July 2024 Cureus, 16(7), e65281

DOI 10.7759/cureus.65281 PMID 39184795 PMC PMC11343067

Abstract

In vitro maturation (IVM) of oocytes represents an assisted reproductive technique that involves the minimal or absence of ovarian stimulation and is beneficial to specific groups of patients. It is based on the collection of immature cumulus-oocyte complexes (COCs) from antral follicles, which are cultured in vitro until they reach the metaphase II (MII) stage. Once maturation is completed, IVM oocytes are normally fertilized, as during a conventional IVF protocol. On the other hand, ovarian rejuvenation through the intraovarian platelet-rich plasma (PRP) injection represents an innovative procedure intended to restore ovarian fertility and development, and it is used to enhance ovarian stimulation outcomes. Here, we report a case of a 47-year-old woman who underwent an assisted reproductive technology cycle (ART) with PRP injection and IVM, which resulted in a successful pregnancy.

Topics

Assisted Reproduction Add-Ons and Adjuncts Adjunct Evidence Base

Assisted Reproduction › Add-Ons and Adjuncts › Adjunct Evidence Base

Nikos Petrogiannis, Kalliopi Chatzovoulou, Maria Filippa, Savvas Petrogiannis, Katerina Chatzimeletiou

N Petrogiannis, K Chatzovoulou, M Filippa, S Petrogiannis, K Chatzimeletiou

PMID 39184795 39184795 DOI 10.7759/cureus.65281 10.7759/cureus.65281 Petrogiannis et al. 2024, Petrogiannis 2024

Keywords

blastocyst, in vitro maturation, live birth, oocyte, ovarian rejuvenation

Successful Pregnancy Following Platelet-Rich Plasma Intraovarian Injection and In Vitro Maturation of Oocytes in a 47-Year-Old Woman: A Case Report

Abstract

Topics

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Keywords