Bayram, F., Sahin, Y., Keleştimur, F., Tutuş, A., Ayata, D., & Müderris, I. I. (1996). The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. Fertility and Sterility, 66(2), 220-222. https://doi.org/10.1016/s0015-0282(16)58442-8
Bayram F, Sahin Y, Keleştimur F, Tutuş A, Ayata D, Müderris II. The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. Fertil Steril. 1996;66(2):220-222. doi:10.1016/s0015-0282(16)58442-8
Bayram, F., et al. "The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism." Fertility and Sterility, vol. 66, no. 2, 1996, pp. 220-222.
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To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism.
Design
Nonrandomized, prospective clinical trial.
Patients
Forty-one patients with moderate-severe hirsutism were included in the study.
Intervention
Hirsute patients received 250 mg/d flutamide for a period of 6 months.
Main Outcome Measures
Hirsutism score, FSH, LH, E2, total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment.
Results
Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48 +/- 5.35 to 5.07 +/- 2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study.
Conclusion
The low-dose flutamide, 250 mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750 mg/d.
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