The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism

Bayram F, Sahin Y, Keleştimur F, Tutuş A, Ayata D, Müderris II

doi:10.1016/s0015-0282(16)58442-8

The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism

İptisam İpek Müderris, Fahri Bayram, Ahmet Tutuş, D Ayata, Fahrettin Keleştimur, Y Sahin

Author affiliations

Erciyes University ROR

Fertility and Sterility, 66(2), 220-222, 1996

DOI 10.1016/s0015-0282(16)58442-8 PMID 8690105

Abstract

Objective

To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism.

Design

Nonrandomized, prospective clinical trial.

Patients

Forty-one patients with moderate-severe hirsutism were included in the study.

Intervention

Hirsute patients received 250 mg/d flutamide for a period of 6 months.

Main Outcome Measures

Hirsutism score, FSH, LH, E2, total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment.

Results

Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48 +/- 5.35 to 5.07 +/- 2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study.

Conclusion

The low-dose flutamide, 250 mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750 mg/d.

Topics

Reproductive Endocrinology > Androgens > Antiandrogen Therapy PCOS > Treatment > Hirsutism Management General OB/GYN > Hirsutism > Pharmacological Treatment

low dose flutamide 250mg hirsutism treatment, flutamide antiandrogen hirsutism score reduction, flutamide hirsutism women hormonal levels prospective trial, antiandrogen therapy moderate severe hirsutism efficacy, flutamide DHEAS testosterone sex hormone binding globulin, cost effective hirsutism treatment low dose flutamide, flutamide 250mg versus 500mg hirsutism comparison, Bayram Sahin flutamide hirsutism clinical trial, androgen excess hirsutism pharmacological treatment women, nonrandomized prospective trial antiandrogen hirsutism women

PMID 8690105 8690105 DOI 10.1016/s0015-0282(16)58442-8 10.1016/s0015-0282(16)58442-8

Cite this article

Müderris, I. I., Bayram, F., Sahin, Y., Keleştimur, F., Tutuş, A., & Ayata, D. (1996). The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. *Fertility and sterility*, *66*(2), 220-222. https://doi.org/10.1016/s0015-0282(16)58442-8

Keywords

Adolescent, Adult, Androgen Antagonists/therapeutic Use, Androstenedione/blood, Dose-Response Relationship, Drug, Estrogens/blood, Female, Flutamide/therapeutic Use, Follicle Stimulating Hormone/blood, Hirsutism/blood/drug Therapy, Humans, Luteinizing Hormone/blood, Progesterone/blood, Prospective Studies, Testosterone/blood, Androgen Antagonists, Estrogens, Testosterone, Androstenedione, Progesterone, Flutamide, Luteinizing Hormone, Follicle Stimulating Hormone

The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism

Abstract

Topics

Cite this article

Keywords

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