C-reactive protein: a limited test for managing patients with preterm labor or preterm rupture of membranes?

J. M. Ernest; Melissa Swain; Steven M. Block; Lewis H. Nelson; Christos G. Hatjis; Paul J. Meis

doi:10.1016/0002-9378(87)90306-1

Birth and Delivery · Labor and Birth

C-reactive protein: a limited test for managing patients with preterm labor or preterm rupture of membranes?

Ernest JM, Swain M, Block SM, Nelson LH, Hatjis CG, Meis PJ

Published February 1987 American Journal of Obstetrics and Gynecology, 156(2), 449-454

DOI 10.1016/0002-9378(87)90306-1 PMID 3826184

Abstract

C-reactive protein has been used to identify patients at high risk for infectious morbidity with preterm labor or preterm rupture of membranes. In this article we report on 104 patients with preterm labor symptoms (n = 45) or preterm rupture of the membranes (n = 59) and serial evaluations of C-reactive protein measured by latex agglutination and laser nephelometry. The simple, inexpensive latex method appears comparable to the laser method in predicting infectious morbidity and can be used clinically. Elevated C-reactive protein values before delivery predict infectious morbidity in only 8% to 29% of patients, and up to 18% of patients with serious infections may be misdiagnosed as having normal C-reactive protein values before delivery.

Topics

Birth and Delivery › Labor and Birth › Induction of Labor · Pregnancy › Preterm Birth › Infection and Inflammation · General Gynecology › Infections › Vaginal and Cervical Infections

Melissa Swain, Steven M. Block, Lewis H. Nelson, Christos G. Hatjis, Paul J. Meis

M Swain, Steve Block, S Block, L Nelson, C Hatjis, P Meis

PMID 3826184 3826184 DOI 10.1016/0002-9378(87)90306-1 10.1016/0002-9378(87)90306-1 Ernest et al. 1987, Ernest 1987

Keywords

C-Reactive Protein/analysis, Chorioamnionitis/diagnosis, Female, Fetal Diseases/diagnosis, Fetal Membranes, Premature Rupture/therapy, Humans, Infections/diagnosis, Obstetric Labor, Premature/therapy, Pregnancy, C-Reactive Protein

C-reactive protein: a limited test for managing patients with preterm labor or preterm rupture of membranes?

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