Reproductive Endocrinology · Neuroendocrinology

Clinical applications of LHRH and its analogues

Sandow J

Published June 1983 Clinical Endocrinology, 18(6), 571-592
DOI 10.1111/j.1365-2265.1983.tb00595.x PMID 6136347

Abstract

The physiological requirement for activation of pituitary gonadotrophin secretion by pulsatile LHRH stimulation is discussed, and compared with the effect of pituitary stimulation by LHRH agonists. Initial stimulation is followed by a phase of progressive pituitary and gonadal inhibition. This inhibition is fully reversible at the end of agonist treatment. Clinical applications of high dose suppression are the treatment of precocious puberty and hormone-dependent tumours (mammary and prostatic carcinoma). In women, agonist administration by nasal spray is a reversible method of inhibiting ovulation, and may also be useful in the treatment of endometriosis. Clinical advantages of agonist therapy are favourable biological tolerance, lack of side effects and rapid reversibility.

Topics

Related research

Reproductive Endocrinology › Neuroendocrinology › Hypothalamic Pituitary Axis · Therapeutics › Hormonal Agents › Gonadotropins
PMID 6136347 6136347 DOI 10.1111/j.1365-2265.1983.tb00595.x 10.1111/j.1365-2265.1983.tb00595.x Sandow et al. 1983, Sandow 1983