CLOMIPHENE CITRATE: FURTHER OBSERVATIONS ON ITS USE IN INDUCTION OF OVULATION IN THE HUMAN AND ON ITS MODE OF ACTION

Roy S; Jungck EC; Greenblatt RB; Mahesh VB

doi:10.1016/s0015-0282(16)35041-5

Reproductive Endocrinology Ovulation Physiology

CLOMIPHENE CITRATE: FURTHER OBSERVATIONS ON ITS USE IN INDUCTION OF OVULATION IN THE HUMAN AND ON ITS MODE OF ACTION

Roy S, Jungck EC, Greenblatt RB, Mahesh VB

Published November 1963 Fertility and Sterility, 14(6), 575-595

DOI 10.1016/s0015-0282(16)35041-5 PMID 14077323

Abstract

Induction of ovulation in the human has been of considerable research interest for several decades. Various hormonal regimens and other procedures have been tried in the past.1 • 2 In spite of all these trials, the problem of ovulatory failure remains a frustrating dilemma for the physician. Recently, the induction of ovulation with clomiphene citrate in about 70% of anovulatory women was reported by our group.3- 6 It was felt that an important breakthrough in this difficult field of endeavor was at hand. 7- 9 Our observations have been confirmed by other groups of investigators.10- 12 The present report embodies a detailed analysis of the results of administration of this agent to 200 women, of whom 179 were anovulatory. The results of our studies on the probable mode of action of this drug are also discussed.

Topics

Reproductive Endocrinology › Ovulation Physiology › Anovulation · Menstrual Cycle › Cycle Disorders › Ovulatory Disturbances · Therapeutics › Ovulation Agents › Selective Estrogen Receptor Modulators

PMID 14077323 14077323 DOI 10.1016/s0015-0282(16)35041-5 10.1016/s0015-0282(16)35041-5 Roy et al. 1963, Roy 1963

Keywords

Abortion, Induced, Amenorrhea, Chemical Phenomena, Chemistry, Child, Clomiphene, Cysts, Female, Humans, Infertility, Infertility, Female, Menstruation Disturbances, Ovarian Neoplasms, Ovulation, Pharmacology, Polycystic Ovary Syndrome, Pregnancy, Puberty, Puberty, Precocious, Sexual Maturation, Stilbenes, Toxicology, Uterine Hemorrhage, Stilbenes, Clomiphene, ABORTION, AMENORRHEA, CHEMISTRY, CHILD, CYSTS, MENSTRUATION DISORDERS, OVARIAN NEOPLASMS, OVULATION, PHARMACOLOGY, PREGNANCY, PUBERTY, PRECOCIOUS, STEIN-LEVENTHAL SYNDROME, STERILITY, FEMALE, STILBENES, TOXICOLOGIC REPORT, UTERINE HEMORRHAGE

CLOMIPHENE CITRATE: FURTHER OBSERVATIONS ON ITS USE IN INDUCTION OF OVULATION IN THE HUMAN AND ON ITS MODE OF ACTION

Abstract

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