Therapeutics · Emerging Therapies
Abstract
During the first several weeks following lactation, nipple pain frequently prevents mothers from continuing breastfeeding. To evaluate the efficacy of using Photobiomodulation (PBM) versus anti-inflammatory topical cream, on inflamed nipple, and the effect on milk production. This study was carried-out on 50 breastfeeding women with nipple pain and fissure. Our patients were divided into two groups ; study group (Group I): 25 patients received 12 sessions of PBM using Diode laser for a period of 4 weeks, 3 sessions per week every alternative day, and controlled group (Group II): 25 patients used Anti-inflammatory topical cream. Regarding inflammatory signs in both groups, Group I showed a significant decrease in redness compared to Group II at the 3rd and 4th week, and a significant decrease in nipple fissure and pain at the 3rd week. There was a significant increase in milk amount reflected on the infant's weight. We concluded that PBM was more effective in decreasing nipple pain, inflammation and subsequently milk production and infant weight than topical anti-inflammatory creams.
Topics
By this author
Labor and Birth · Induction of Labor
Laser acupuncture effect on fetal well-being during induction of labor
Alsharnoubi J et al., 2015 · Lasers in medical science
Labor induction with traditional drugs is sometimes associated with fetal complications as fetal distress or death. The aim of this study was to evaluate the effect of labor induction by laser acupuncture on fetal well-being in post-term pregnancy. Nulliparous women at 40 weeks or greater were randomized to sham laser group versus laser acupuncture group. Each session consisted of laser application on bilateral points LI 4, SP 6, BL 31, and BL 32. The study was conducted in Cairo University, National Institute of Laser Enhanced Sciences. Sixty nulliparous women were randomized into laser acupuncture group n = 30 and control group n = 30. Women were treated in both groups in three consecutive days in post-date pregnancy. Results (66.6%) showed a significant difference in rate of normal vaginal delivery (NVD) between acupuncture group (50%) and control group (50%) (p = 0.002). There was no significant difference of enrollment delivery time between laser acupuncture and sham groups (p > 0.05). There were six cases of cesarean section (CS) due to no fetal movement with normal cardiotocography (CTG). Laser acupuncture has no effect on fetus, and its effect on fetal movement needs more investigations. Laser can induce labor if the cervical length is less than 1 cm and dilation (0).
Related research
Emerging Therapies · Light Therapy
Effects of 660-nm Photobiomodulation Therapy on Pain and Healing of Nipple Trauma in Lactating Women: A Pilot Randomized Double-Blind Controlled Trial
Moraes BHM et al., 2026 · Research Square (preprint)
Abstract To evaluate the effects of PBMT (λ = 660 nm) on pain, breastfeeding quality, and healing of nipple injuries. This randomized, double-blind, controlled pilot trial included 20 lactating postpartum women with nipple trauma. Participants were divided into PBMT (standard care + active PBMT) and Placebo (standard care + sham) groups. Interventions occurred up to seven sessions over 15 days. PBMT parameters: 660 nm, 40 mW, 10 J/cm², and 0.4 W/cm² for 10s per point (one central and four peripheral points). Assessments included the Visual Analogue Scale (VAS), LATCH Scale, Nipple Trauma Score (NTS), and photogrammetry. Most participants (90%) presented bilateral excoriations or fissures. The PBMT group showed significantly greater pain reduction from the third session onward (p < 0.05), achieving total analgesia by the seventh, whereas the Placebo group maintained higher VAS scores. Although both groups improved their breastfeeding technique, the PBMT group showed superior post-intervention LATCH scores. Furthermore, PBMT significantly accelerated tissue repair from the third session onward. The PBMT group reached complete lesion regression (NTS = 0), while the Placebo group maintained residual trauma (NTS = 1). PBMT combined with clinical management is effective for pain relief, tissue repair, and improving breastfeeding quality. It serves as a promising adjuvant resource to prevent complications and support the maintenance of exclusive breastfeeding.
Emerging Therapies · Light Therapy
Low-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis
Gaitero MVC et al., 2025 · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
This study aimed to investigate the effect of low-level laser therapy (LLLT) on nipple trauma and pain during breastfeeding through a systematic review with a meta-analysis of selected studies. A thorough search was conducted on March 22, 2022, using the databases PubMed, SciELO, LILACS, PEDro, CINAHL, EMBASE, ScienceDirect, Scopus, Google Scholar, MEDLINE, the Cochrane Library, Clinical Trials, Web of Science, TRIP, DARE, and ProQuest. The search terms included various combinations of low-level laser therapy, nipple pain, nipple trauma, and breastfeeding. Out of 107 articles identified, only three controlled and randomized clinical trials was included. The extracted data encompassed breast and trauma characteristics, treatment types, outcomes (pain and healing process), evaluation tools, LLLT usage, laser brand, and parameters. Data extraction was performed using RAYYAN for systematic reviews. The risk of bias in the studies was evaluated. Pain was measured using the visual analog scale (VAS). The included studies did not use validated tools for assessing physical conditions. All studies employed LLLT with a 660-nm wavelength, though there were variations in equipment power, energy dose, and application methods. The meta-analysis revealed an average difference of -0.60 points (95% CI: -1.52 to 0.31) in the VAS pain scores between the LLLT and control groups. No heterogeneity was observed among the studies (I2=0%), indicating no significant difference in pain relief between LLLT (red light) and control groups. LLLT may offer a promising option for managing breastfeeding-related complications, though further research is required.
Emerging Therapies · Light Therapy
The Effect of Photobiomodulation on Analgesia During Childbirth: A Controlled and Randomized Clinical Trial
Traverzim MA et al., 2021 · Photobiomodulation, photomedicine, and laser surgery
Pain during labor can be a barrier when choosing vaginal delivery. In an attempt to relief pain during labor, several pharmacological and nonpharmacological methods are proposed. To assess the effect of light-emitting diode (LED) photobiomodulation on analgesia during labor. A clinical trial was conducted with 29 women who were divided into two groups: G1 (experimental group-LED) and G2 (control group-hot shower). In the experimental group, an LED plate with red and infrared merged [red 660 ± 20 nm, 5 mW/cm2, 3 J per LED (108 J) and infrared 850 ± 20 nm, 5 mW/cm2, 3 J per LED (108 J), total energy = 216 J] was placed on the subjects' dorsal region, at the level of T10 to S4, for 10 min, with the plate automatically turning off. Hot shower at controlled temperature was offered for 30 min. To verify the effect of LED on analgesia during labor, the following variables were assessed: (1) perception of pain, (2) fetal well-being assessed by cardiotocography or intermittent auscultation of fetal heart rate, (3) Apgar score at minutes 1 and 5 after birth, and (4) labor duration. There was a statistically significant difference (p < 0.05) in pain reduction evidenced by a millimetric visual scale, before and after application on G1-LED (7.92 ± 1.78). Regarding the other variables, there was no statistical difference between the groups when comparing fetal well-being, Apgar score and labor duration. It is concluded that LED can be considered an alternative, since it caused pain reduction without changing other parameters during labor, compared with hot shower, a method included in hospital protocols, proving to be safe. Clinical NCT03496857.
Emerging Therapies · Light Therapy
Influence of Photobiomodulation Therapy Combined with Pelvic Floor Exercises on Postpartum Coccydynia: A Randomized Controlled Trial
Abdoelmagd SR et al., 2025 · Photobiomodulation, photomedicine, and laser surgery
This study was conducted to investigate whether the addition of photobiomodulation therapy (PBMT) to pelvic floor exercises (PFEs) is more effective in treating postpartum coccydynia compared with either modality alone. Postpartum coccydynia is a widespread condition that significantly affects the quality of life. Inflammation as a response to childbirth trauma and weakening of the muscles and ligaments attached to the coccyx are presumed causes of postpartum coccydynia. Finding effective modalities to manage this condition will help the quality of life for most women. Sixty women aged 25-35 years with postpartum coccydynia ≥6 weeks were randomly allocated to Group A (PBMT + hot pack + PFEs), Group B (PBMT + hot pack), and Group C (placebo PBMT + hot pack + PFEs). All groups received 12 sessions over 4 weeks of hot packs plus their allocated active treatment (PBMT and/or PFEs). Outcomes were pain intensity (visual analog scale), lumbar flexion range of motion (ROM) (modified Schober test), and self-reported disability (Oswestry Disability Index). The assessors were blinded to group allocation. All the measured outcomes showed significant differences (p < 0.001), with the superiority of Group A over the other groups (p < 0.001). Within groups, all groups showed statistically significant improvement from baseline across outcomes (p < 0.05). Adding PBMT to PFEs is recommended in the management of postpartum coccydynia as this combination resulted in greater reductions in pain and disability, along with improved lumbar flexion ROM.
Therapeutics › Emerging Therapies › Light Therapy · Postpartum › Infant Feeding › Breastfeeding Support · General Gynecology › Breast Health › Benign Breast Conditions
Maha Helmy Ammar Ahmed Elseody, Marwa Abd El-Rahman Mohamed, Jehan Alsharnoubi
M Elseody, M Mohamed, J Alsharnoubi
PMID 39046567 39046567 DOI 10.1007/s10103-024-04132-w 10.1007/s10103-024-04132-w Elseody MHAA et al. 2024, Elseody MHAA 2024