Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF2α

Qiqi Fu; Jiali Yang; Hui Jiang; Shangfei Lin; Haokuan Qin; Jie Zhao; Yanqing Wang; Muqing Liu

doi:10.1002/jbio.202300448

Therapeutics · Emerging Therapies

Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF2α

Fu Q, Yang J, Jiang H, Lin S, Qin H, Zhao J, Wang Y, Liu M

Journal of biophotonics, 2024

DOI 10.1002/jbio.202300448 PMID 38348528

Abstract

Photobiomodulation (PBM) has attracted widespread attention in suppressing various pain and inflammation. Primary dysmenorrhea (PD) primarily occurs in adolescents and adult females, and the limited effectiveness and side effects of conventional treatments have highlighted the urgent need to develop and identify new adjunct therapeutic strategies. In this work, the results of pain and PGs demonstrated that 850 nm, 630 nm, and 460 nm all exhibited pain inhibition, decreased PGF2α and upregulated PGE2, while 630 nm PBM has better effectiveness. Then to explore the underlying biological mechanisms of red light PBM on PD, we irradiated prostaglandin-F2α induced HUSM cells and found that low-level irradiance can restore intracellular calcium ion, ROS, ATP, and MMP levels to normal levels. And, red light enhanced cell viability and promoted cell proliferation for normal HUSM cells. Therefore, this study proposes that red light PBM may be a promising approach for the future clinical treatment of PD.

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Emerging Therapies · Light Therapy

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A growing body of evidence supports the modulation of pain by light exposure. As such, phototherapy is being increasingly utilized for the management of a variety of pain conditions. The modes of delivery, and hence applications of phototherapy, vary by wavelength, intensity, and route of exposure. As such, differing mechanisms of action exist depending upon those parameters. Cutaneous application of red light (660 nm) has been shown to reduce pain in neuropathies and complex regional pain syndrome-I, whereas visual application of the same wavelength of red light has been reported to exacerbate migraine headache in patients and lead to the development of functional pain in animal models. Interestingly visual exposure to green light can result in reduction in pain in variety of pain conditions such as migraine and fibromyalgia. Cutaneous application typically requires exposure on the order of minutes, whereas visual application requires exposure on the order of hours. Both routes of exposure elicit changes centrally in the brainstem and spinal cord, and peripherally in the dorsal root ganglia and nociceptors. The mechanisms of photobiomodulation of pain presented in this review provide a foundation in furtherance of exploration of the utility of phototherapy as a tool in the management of pain. This review synopsizes the pathways and mechanisms through which light modulates pain and the therapeutic utility of different colors and exposure modalities of light on pain. Recent advances in photobiomodulation provide a foundation for understanding this novel treatment for pain on which future translational and clinical studies can build upon.

Therapeutics › Emerging Therapies › Light Therapy · General Gynecology › Pelvic Pain › Chronic Pelvic Pain · Menstrual Cycle › Cycle Disorders › Dysmenorrhea

Qiqi Fu, Jiali Yang, Hui Jiang, Shangfei Lin, Haokuan Qin, Jie Zhao, Yanqing Wang, Muqing Liu

Q Fu, J Yang, H Jiang, S Lin, H Qin, J Zhao, Y Wang, M Liu

PMID 38348528 38348528 DOI 10.1002/jbio.202300448 10.1002/jbio.202300448 Fu et al. 2024, Fu 2024

Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF2α

Abstract

Topics

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Photobiomodulation therapy at 632 nm wavelength ameliorates intrauterine adhesion via activation of cAMP/PKA/CREB pathway

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New Insights into Photobiomodulation of the Vaginal Microbiome-A Critical Review

Mechanisms and Pathways of Pain Photobiomodulation: A Narrative Review