Interstitial cystitis associated with primary Sjögren's syndrome successfully treated with a combination of tacrolimus and corticosteroid: A case report and literature review

Yo Ueda; Hikaru Tomoe; Hiroyuki Takahashi; Yuko Takahashi; Hiroyuki Yamashita; Hiroshi Kaneko; Toshikazu Kano; Akio Mimori

doi:10.3109/14397595.2014.895283

Autoimmune and Inflammatory Disease · Chronic Pain and Bladder Syndromes

Interstitial cystitis associated with primary Sjögren's syndrome successfully treated with a combination of tacrolimus and corticosteroid: A case report and literature review

Ueda Y, Tomoe H, Takahashi H, Takahashi Y, Yamashita H, Kaneko H, Kano T, Mimori A

Modern rheumatology, 26(3), 445-449, 2016

DOI 10.3109/14397595.2014.895283 PMID 24720552

Abstract

We report a case of interstitial cystitis (IC) associated with primary Sjögren's syndrome (SS) successfully controlled with combination therapy of tacrolimus and a corticosteroid. In 2011, a 69-year-old female, who had been diagnosed with primary SS 23 years ago, developed IC and was successfully treated with tacrolimus and prednisolone combination therapy. The mechanism of IC, including the involved autoimmunity, has not been elucidated. Clinical observation studies suggest a potential association between SS and IC. However, IC is currently thought to be underdiagnosed in patients with SS as well as in the general population. Based on our case and others reported previously, IC associated with SS responds well to immunosuppressive therapy. In particular, a combination of a calcineurin inhibitor (tacrolimus or cyclosporine) with a corticosteroid seems to be highly effective. The possibility of IC in patients with SS complaining of lower urinary tract symptoms without features of infection or other identifiable causes should be given attention.

Topics

Autoimmune and Inflammatory Disease Chronic Pain and Bladder Syndromes Interstitial Cystitis

Autoimmune and Inflammatory Disease › Chronic Pain and Bladder Syndromes › Interstitial Cystitis

Yo Ueda, Hikaru Tomoe, Hiroyuki Takahashi, Yuko Takahashi, Hiroyuki Yamashita, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori

Y Ueda, H Tomoe, H Takahashi, Y Takahashi, H Yamashita, H Kaneko, T Kano, A Mimori

PMID 24720552 24720552 DOI 10.3109/14397595.2014.895283 10.3109/14397595.2014.895283 Ueda et al. 2016, Ueda 2016

Interstitial cystitis associated with primary Sjögren's syndrome successfully treated with a combination of tacrolimus and corticosteroid: A case report and literature review

Abstract

Topics

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