Jones, G. S., Maffezzoli, R. D., Strott, C. A., Ross, G. T., & Kaplan, G. (1970). Pathophysiology of reproductive failure after clomiphene-induced ovulation. American journal of obstetrics and gynecology, 108(6), 847-67. https://doi.org/10.1016/0002-9378(70)90327-3
Jones GS, Maffezzoli RD, Strott CA, Ross GT, Kaplan G. Pathophysiology of reproductive failure after clomiphene-induced ovulation. American journal of obstetrics and gynecology. 1970;108(6):847-67. doi:10.1016/0002-9378(70)90327-3
Jones, G. S., et al. "Pathophysiology of reproductive failure after clomiphene-induced ovulation." American journal of obstetrics and gynecology, vol. 108, no. 6, 1970, pp. 847-67.
70 patients with infertility were evaluated after clomiphene-induced ovulation to determine the cause of the low rate of conceptions and subsequent viable pregnancies. Ovarian function was measured employing the usual clinical techniques. In a select group of 4, plasma luteotropic hormone, follicle stimulating hormone, progesterone, and 17-hydroxyprogesterone were measured an ovarian biopsies were obtained. From these studies, 2 groups could be defined. The 1st was found to have normal luteal function followed by a relatively high incidence of successful pregnancy. The 2nd group demonstrated abnormal luteal function with only 1 successful pregnancy. Ovarian biopsies from 2 patients in the 2nd group showed inadequate luteinization of the granulosa cells, a finding which appeared to correlate with abnormal gonadotropin stimulation. These data would suggest that gonadotropin requirements for adequate corpus luteum function are separate from those required for ovualtion.
