Pivotal role of boron supplementation on bone health: A narrative review

Mariangela Rondanelli; Milena Anna Faliva; Gabriella Peroni; Vittoria Infantino; Clara Gasparri; Giancarlo Iannello; Simone Perna; Antonella Riva; Giovanna Petrangolini; Alice Tartara

doi:10.1016/j.jtemb.2020.126577

Lifestyle and Environment · Nutrition and Metabolic Health

Pivotal role of boron supplementation on bone health: A narrative review

Rondanelli M, Faliva MA, Peroni G, Infantino V, Gasparri C, Iannello G, Perna S, Riva A, Petrangolini G, Tartara A

Published December 2020 Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 62, 126577

DOI 10.1016/j.jtemb.2020.126577 PMID 32540741

Abstract

Background

Boron is a trace element that plays an important role in numerous biological functions, including calcium metabolism, growth and maintenance of bone tissue. However, there are still no precise indications regarding a possible role of boron supplementation, and its amount of supplementation, to maintain bone health. So the aim of this narrative review was to consider the state of the art on the effectiveness of boron supplementation (alone or with other micronutrients) on growth and maintenance of bone in humans through control of calcium, vitamin D and sex steroid hormone metabolism in order to suggest a daily dosage of boron supplementation.

Main Findings

This review included 11 eligible studies: 7 regarding the supplementation with boron alone and 4 regarding supplementation with boron and other nutrients. Despite the number of studies considered being low, the number of subjects studied is high (594) and the results are interesting.

Conclusions

The studies considered in this narrative review have evaluated the positive effectiveness on bone, in humans, through control of calcium, vitamin D and sex steroid hormone metabolism, considering a dietary supplementation of 3 mg/day of boron (alone or with other nutrients); this supplementation is demonstrably useful to support bone health (in order to prevent and maintain adequate bone mineral density), also considering the daily dose of 3 mg is much lower than the Upper Level indicated by EFSA in the daily dose of 10 mg.

Topics

Lifestyle and Environment › Nutrition and Metabolic Health › Dietary Patterns · Bone Health › Bone Mineral Density › Peak Bone Mass

Mariangela Rondanelli, Milena Anna Faliva, Gabriella Peroni, Vittoria Infantino, Clara Gasparri, Giancarlo Iannello, Simone Perna, Antonella Riva, Giovanna Petrangolini, Alice Tartara

M Rondanelli, M Faliva, G Peroni, V Infantino, C Gasparri, G Iannello, S Perna, A Riva, G Petrangolini, A Tartara

PMID 32540741 32540741 DOI 10.1016/j.jtemb.2020.126577 10.1016/j.jtemb.2020.126577 Rondanelli et al. 2020, Rondanelli 2020

Keywords

Bone, Bone mineral density, Boron, Dietary supplementation, Nutrients

Pivotal role of boron supplementation on bone health: A narrative review

Abstract

Topics

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Keywords