Progesterone therapy in women with complex partial and secondary generalized seizures

Andrew G. Herzog

doi:10.1212/wnl.45.9.1660

Therapeutics · Hormonal Agents

Progesterone therapy in women with complex partial and secondary generalized seizures

Herzog AG

Published September 1995 Neurology, 45(9), 1660-1662

DOI 10.1212/wnl.45.9.1660 PMID 7675223

Abstract

This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures. Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p < 0.01). Average daily CPS frequency declined by 54% (p < 0.01), SGMS by 58% (p < 0.02).

Topics

Therapeutics › Hormonal Agents › Progesterone and Progestins · Reproductive Endocrinology › Neuroendocrinology › Hypothalamic Pituitary Axis

Andrew G. Herzog

Andy Herzog, Drew Herzog, A Herzog

PMID 7675223 7675223 DOI 10.1212/wnl.45.9.1660 10.1212/wnl.45.9.1660 Herzog et al. 1995, Herzog 1995

Keywords

Adolescent, Adult, Epilepsy, Complex Partial/drug Therapy, Epilepsy, Generalized/drug Therapy, Female, Humans, Progesterone/therapeutic Use, Progesterone

Progesterone therapy in women with complex partial and secondary generalized seizures

Abstract

Topics

By this author

Reproductive endocrine considerations and hormonal therapy for women with epilepsy

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Keywords