Review on autoimmune reactions in female infertility: antibodies to follicle stimulating hormone

Kadri Haller-Kikkatalo; Andres Salumets; Raivo Uibo

doi:10.1155/2012/762541

Reproductive Endocrinology · Ovarian Hormones

Review on autoimmune reactions in female infertility: antibodies to follicle stimulating hormone

Haller-Kikkatalo K, Salumets A, Uibo R

Clinical & developmental immunology, 2012, 762541, 2012

DOI 10.1155/2012/762541 PMID 22007255 PMC PMC3189473

Abstract

Female fertility can be affected by diseases or dysfunctions of reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with overall activation of immune system or with immune system reactions specifically directed against ovarian antigens. Majority of the antiovarian autoantibodies are directed against β-subunit of follicle stimulating hormone (anti-FSH). This paper summarizes a current clinical classification of female infertility in the context of general activation of autoimmunity and antiovarian autoimmunity by describing serum anti-FSH. The presence of naturally occurring anti-FSH in healthy women will be discussed. In addition, the putative impairment of ovarian folliculogenesis in case of increased production of those antibodies in infertile women will be characterized.

Topics

Reproductive Endocrinology › Ovarian Hormones › Estrogen · Diagnostics › Genetic and Immune Testing › Autoimmune and Thrombophilia Panels · Genetics and Immunology › Reproductive Immunology › Autoimmune Conditions and Fertility

Kadri Haller-Kikkatalo, Andres Salumets, Raivo Uibo

K Haller-Kikkatalo, A Salumets, R Uibo

PMID 22007255 22007255 DOI 10.1155/2012/762541 10.1155/2012/762541 Haller-Kikkatalo et al. 2012, Haller-Kikkatalo 2012

Review on autoimmune reactions in female infertility: antibodies to follicle stimulating hormone

Abstract

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