The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 24(4), 260-265, 2019
Short- and long-term effect of contraceptive methods on fecundity
Olof Lundberg, Simon P Rowland, James Trussell
Kristina Gemzell‐Danielsson, Jan Holte, Helena Kopp Kallner, Berglund Scherwitzl E , Kopp Kallner H , Gemzell Danielsson K , Elina Berglund Scherwitzl , Kristina Gemzell-Danielsson , Raoul Scherwitzl
Author affiliations (6)
Natural Cycles USA Corp, New York, New York, USA.ROR
Princeton University; Office of Population research; Wallaca Hall Princeton New Jersey USA NJ 08544ROR
The aim of the study was to compare the effect of previously used contraceptive methods on women's shortand long-term fecundity. Use of hormonal contraception (HC) was compared with the use of a contraceptive mobile application (app).
Methods
This real-life prospective observational study comprised 2874 women who were attempting to become pregnant using the Natural Cycles mobile app to monitor their fertility. The women registered to use the app between August 2014 and June 2016 with the intention of planning a pregnancy and had previously either used the same app to prevent pregnancy or had recently discontinued HC use. We calculated the average time to pregnancy (TTP) for all women who became pregnant during the study and performed Kaplan-Meier life-table analysis to examine the cumulative probabilities of pregnancy for all women in the study.
Results
The average TTP was 2.3 (95% confidence interval [CI] 2.1, 2.4) and 3.7 (95% CI 3.4, 3.9) cycles for women who had previously used Natural Cycles and HC, respectively. The time to reach 30% pregnancy probability for women previously on HC was 1.6 (95% CI 1.5, 1.8) times longer than for women previously using Natural Cycles. There was no significant difference in the 13 cycle cumulated pregnancy probability between the two groups.
Conclusion
The results show that fertility awareness-based methods of contraception increase short-term pregnancy rates relative to HC, but have no effect on long-term pregnancy rates.
PMID 31223036 31223036 DOI 10.1080/13625187.2019.1621999 10.1080/13625187.2019.1621999
Cite this article
Berglund Scherwitzl, E., Lundberg, O., Kopp Kallner, H., Rowland, S. P., Holte, J., Trussell, J., Gemzell Danielsson, K., & Scherwitzl, R. (2019). Short- and long-term effect of contraceptive methods on fecundity. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 24(4), 260-265. https://doi.org/10.1080/13625187.2019.1621999
Berglund Scherwitzl E, Lundberg O, Kopp Kallner H, Rowland SP, Holte J, Trussell J, et al. Short- and long-term effect of contraceptive methods on fecundity. Eur J Contracept Reprod Health Care. 2019;24(4):260-265. doi:10.1080/13625187.2019.1621999
Berglund Scherwitzl, E., et al. "Short- and long-term effect of contraceptive methods on fecundity." The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, vol. 24, no. 4, 2019, pp. 260-265.
Keywords
Contraceptive Agents, Hormonal
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